Release method

Review of Pharmaceutical Controlled Release Methods and Devices. Paul A. Steward, http //www.initium.demon.co.Uk/rel nf.htm Drug Deliv... 

Table 1 Apparatus Recommended Based on Dosage Form Type Type of dosage form Release method...

A solid phase library synthesis method based on the Fischer indole synthesis was developed (Scheme A resin-capture-release method... 

Receptor-mediated endocytosis may be possible because receptors have a high affinity for BDNF (Deckner et al. 1993). A linear relation between intranasal administration of -labeled NGF and brain concentrations of the compound suggest that this transportation is not mediated by receptors and that this releasing method of agents to the brain via olfactory nerves may be effective for many therapies (Frey et al. 1995). BDNF and the insulin-type growth factor (IGF-1) are currently used in clinical studies (Appel 1997). 

Flavor quality—Continued maintenance in natural and synthetic compounds, 56-75 Flavor recognition and transduction, complexity, 10-25 Flavor release, methods, 24,25/... 

And who could forget those tiny time-capsules - coated and timed-released methods already in use. 

An alternative strategy towards benzimidazole synthesis relies on the palladium-catalysed cyclisation of (2-bromophenyl)amidines. This chemistry has been reported to take place under aqueous reaction conditions, in the presence of sodium hydroxide in sealed microwave vials. The products were isolated by a catch and release method using a strongly acidic ion exchange resin, thereby avoiding conventional chromatographic purification (Scheme 3.14)23. Selectively, N-functionalised benzimidazoles were conveniently prepared by this method. 

S. F. Wheeler and D. J. Harvey, Extension of the in-gel release method for structural analysis of neutral and sialylated A-linked glycans to the analysis of sulfated glycans Application to the glycans from bovine thyroid-stimulating hormone, Anal. Biochem., 296 (2001) 92-100. 

Kind, M.,Turk, S., and Vrecer, F. (2005), Application of experimental design methodology (DOE) in development and optimization of drug release method, Int. J. Pharm., 291,39 19. 

It should be noted at this point that the first highly active chemosterilants were developed as alternatives to the radiation-induced mutagenesis employed in the sterile male release method. 

A fluorous catch and release method was used by Zhang in the synthesis of di-substituted pyrimidines.A fluorous route to hydantoins and thiohydantoins was also reported by the same group. 

Though in general the IP and EP DON release rates are similar, short-term variations in the atom % enrichment of the intracellular ON pool can cause some variations between them (Bronk, 1999 Mulholland et al., 2004). The IP DON release rate is also very labor intensive and requires a host of assumptions, and therefore is less robust than the EP DON release method. The IP and EP distinctions are only necessary when both types of rates are being discussed (Bronk and Ward, 2000). 

Profile Analysis of Oligosaccharides from Glycoproteins by PMP Labeling. Comparison of Chemical and Enzymatic Release Methods Using RP-HPLC and Mass Spectrometry... 

Currently, there are no broad-specificity endoglycosidases for 0-linked glycans. To liberate these one must turn to chemical release methods which include hydrazinolysis and beta-elimination. 

The release of Hg from the sample can be accomplished by either reducing Hg in solution with stannous chloride (Hatch and Ott, 1968) or heating the sample. The thermal release method is the most reliable and easiest, provided sufficient precautions are taken. 

As described by Reader S, Blackwell V, O Hara R, et al. (1989) A vital dye release method for assessing the short term cytotoxic effects of chemicals and formulations. Alternatives to Laboratory Animals 17 28-37. 

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