Release biodegradable

Throughout the 1990s a large portion of the research and development effort for hot melt adhesives focused on developing adhesives that are either environmentally friendly or functional [69,81,82]. Environmentally friendly attributes include biodegradability, water dispersibility (repulpability), renewability, and water releasability. Biodegradable adhesives have been developed based on starch esters [83-86] and polyesters such as poly (hydroxy butyrate/hydroxy valerate) [87], poly(lactide) [88-91], and poly(hydroxy ether esters) [92-94]. All but the... 

Kohn, J., Niemi, S. M., Albert, E. C., Murphy, J. C., Danger, R., and Fox, J. G., Single step immunization using a controlled release, biodegradable polymer with sustained adjuvant activity, J. Immunol. Meth., 95. 31-38, 1986. 

Cleland, J. L. (1998), Solvent evaporation processes for the production of controlled release biodegradable microsphere formulations for therapeutics and vaccines, Bio-technol. Prog., 14,102-107. 

One of the ideal situations in the treatment of disease is the delivery of efficacious medication to the site of action in a controlled and continual manner at the appropriate concentration. Controlled-released, biodegradable nanoparticles that can be loaded with the appropriate drug products have been developed to treat conditions such as cancer, arthritis, and osteoporosis. In view of their low toxicity and their protein-binding properties, the nanoparticles may be useful in the oral administration of peptides, proteins, and oligonucleotides, especially for vaccination. 

Controlled-release biodegradable PLG polymers loaded with parathyroid hormone were formulated as a freeze-dried form with particle size ranging from 27 to 47 i. The freeze-dried method did not alter the surface morphology, particle size, and parathyroid hormone content or release rate of the microspheres. The freeze-dried microspheres resuspended very rapidly and uniformly in solution. In vitro release studies indicated that except for a slight early burst ranging from 4-18%, release of parathyroid hormone from the nanoparticles was very slow over the first 14 days. At 15 days, release of parathyroid hormone accelerated rapidly. 

Golumbek PT, Azhari R, Jaffee EM, Levitsky HI, Lazenby A, Leong K, Pardoll DM. Controlled release, biodegradable cytokine depots a new approach in cancer vaccine design. Cancer Res 1993 53 5841-5844. 

Kim, M. Jung, B. Park, J.H. Hydrogel swelling as a trigger to release biodegradable polymer micro needles in skin. Biomaterials 2012, 33 (2), 668-678. 

RamtoolaZ. Controlled release biodegradable micro- and nanospheres containing cyclosporin. US patent 5641745,1997. 

This paper concludes by suggesting that this novel biopolymer at this stage of research displays great potential as a slow-release biodegradable device for the prevention of paediatric dental caries. The amount of drug loading can be easily varied to suit treatment requirements and the design flexibility allows for the most suitable option to be selected in terms of comfort and acceptability. 

This conceptual section deals with the influence of the molecular basis of the SMPs on three SMP functionalities drug release, biodegradability and SME. Therefore, the building blocks, morphologies and architectures of SMPs will be discussed in the context of the functionalities, and furthermore the different strategies for controlling the drug release will be examined. 

Several injectable prolonged release biodegradable microspheres are available as licensed products, e.g. Lupron Depot and Risperdal Consta [18, 19]. The injectable ultrasound contrast agent (Optison ) consists of heat-denaturated albumin microspheres filled with the gas octafluoropropane. In a similar manner sulphur hexafluoride containing microspheres (SonoVue ) are used as injectable contrast agent in echocardiography. 

Yoon, J.J., Kim, J.H., Park, T.G., 2003. Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method. Biomaterials 24, 2323-2329. 

Lo H, PonticieUo MS, Leong KW. Fabrication of controlled release biodegradable foams by phase separation. Tissue Eng 1995 1 15-28. 

Neffe, A. T., Hanh, B. D., Steuer, S., Lendlein, A. (2009). Polymer networks combining controlled drug release, biodegradation, and shape memory capability. Advanced Materials,... 

Minimization of the effects of releases, biodegradability, reduce GHG emissions... 

---