Biodegradable devices

This Gemini cationic surfactant could not be recovered from samples of biodegradation experiments performed in a lab-scale aerobic bioreactor [50] either because of complete biodegradation (mineralisation) or because of irreversible adsorption at the surface of the biodegradation device. 

Most of the commercially available biodegradable devices are polyesters composed of homopolymers or copolymers of glycolide and lactide. There are also devices made from copolymers of trimethylene carbonate and e-caprolactone, and a suture product made from polydioxanone. 

Since EVAc is a non-biodegradable polymer, the implanted device has to be surgically removed from the host after completion of the immunization process. Hence, it would be advantageous to use biodegradable devices for the controlled release of antigen. 

It is safe to assume that for a given dissolution device, the ultimate drug delivery rate will be a combination of hydrolysis (dissolution) and drug diffusion out of the polymer. Of the systems stuped to date, the release rates for biodegradable devices are essentially zero-order. 

This paper concludes by suggesting that this novel biopolymer at this stage of research displays great potential as a slow-release biodegradable device for the prevention of paediatric dental caries. The amount of drug loading can be easily varied to suit treatment requirements and the design flexibility allows for the most suitable option to be selected in terms of comfort and acceptability. 

Another alternative for decreasing rejection and infection rates is the creation of a biodegradable device. A biodegradable cross-linked, elastic salmon collagen scaffold with wall compliance similar to native artery has been used as a vascular graft. 

For example, in the next couple of years, many of the permanent prosthetic devices used for temporary therapeutic applications will be replaced by biodegradable devices that could help the body to repair and regenerate the damaged tissues (36). 

For some medical applications, polymer degradation may be an intended consequence of the medical application, where a permanent device is not required. When a biodegradable device is implanted in the body, a general requirement is that the mechanical properties of the material should not... 

First, a brief overview of the degradation mechanism and the main factors that influence hydrolysis of bioresorbable polymers is provided. Then, the modeling approaches that can be used for characterizing the behavior of biodegradable devices will be summarized. 

Vieira AC, Guedes RM, Marques AT. Development of hgament tissue biodegradable devices a review. J Biomech 2009 42 2421-30. 

Over the past two decades, the trend of using biodegradable materials instead of biostable materials has rapidly emerged in the case of various applications [44]. Because of the diverse features of polymeric materials, biodegradable polymers are rapidly replacing other materials such as metals, alloys, and ceramics [45]. This tremendous increase in the use of biodegradable materials supports the prediction that many of the permanent prosthetic devices used currently will be replaced by biodegradable devices in... 

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