Micro needles

Goldenfeld, I.V. Veith, H.J. A New Emitter for Field-Desorption Mass Spectrometry with Silver-Electroplated Micro-needles. Int. J. Mass Spectrom. Ion Phys. 1981,40, 361-363. 

Shichiri et al(ll) (Osaka University in Japan) has developed the micro needle type glucose sensor, which consisted of a hydrogen peroxide electrode and a GOX enzyme immobilized layer. The sensor was clinically used, but it had to be renewed after a few days because of a gradual decline in its output. 

Guber, A.E., Dittrich, H., Heckele, M., Herrmann, D., Musliga, A., Pfleging, W., Schaller, T., Polymer micro needles with through-going capillaries. Micro Total Analysis Systems, Proceedings 5th pZAS Symposium, Monterey, CA, Oct. 21-25,... 

Flame Vitrification and Spheridization of Silicate Particles. The alumino-silicate particles vitrify and take a spherical shape in the flame and are partially recrystallized on cooling. Micro-needles of mullite up to 10 pm long and crystalloids of quartz are the principal devitrification products enveloped in a glassy material matrix. 

Smooth and skeletal muscle myosins have important functional differences with respect to their motor activities and their regulation. The differences in motor properties are evident in the behavior of smooth and skeletal muscle myosins in an in vitro motifity assay. Purified smooth muscle myosin propels actin filaments at one tenth the velocity of skeletal muscle myosin and produces an average of 3-4 times more force per unit time period than skeletal muscle myosin, as measured by a micro-needle assay (Warshaw et al 1990, Van Buren et al 1994). These differences in the functional properties of smooth and skeletal muscle myosins at the molecular level parallel differences in the functional properties of smooth and skeletal muscle tissues. Smooth muscle tissues produce the same isometric force per cross-sectional area as skeletal muscle, but contain only one fifth as much myosin (Murphy et al 1974). In addition, the maximal shortening velocities of smooth muscle tissues are 1-2 orders of magnitude slower than those of skeletal muscles (Murphy et al 1997). 

S. Shirator, S. Mori, and K. DceyaM, Wire bonding over insulating substrates by electropolymerization of polypynole using a scanning micro-needle. Sens. Actuators B, 49, 30-33 (1998). 

Kim, M. Jung, B. Park, J.H. Hydrogel swelling as a trigger to release biodegradable polymer micro needles in skin. Biomaterials 2012, 33 (2), 668-678. 

Pearton M, Allender C, Brain K, Anstey A, Gateley C, Wilke N, Morrissey A, Birchall J, Gene dehvery to the epidermal cells of human skin explants using microfabricated micro needles and hydrogel formulations. Pharm Res, 2007, 25, 407-16. 

B,2HCl plates from dil. HCl. M.p. 248-9°. Diacetyl deriv. micro-needles from EtOH.Aq. M.p. 220°. 

Me ether CioHoO.. MW, 192. Micro-needles from 30% MeOH. M.p. 171-2°. 

Yellow micro-needles from H O. Decomp, at 265-70°. Sol. EtjO. Spar sol. H O. Prac. insol. CfiHe,... 

Fig. 8.12 Schematic of the IPMC-PVDF sensori-actuator with a micro needle mounted at the tip. Reprinted from [Chen et al. (2007a)j.

Micro-needles from CgHg. M.p. 180-1 (186 ). Spar, sol. EtOH, AcOH, OHOlg, C, . Zn - and 3-linolenic acids. Forms alkiddd salts. Me eater. CigHgijOgBrg MW,. M.p. 157-8 . 

Dipalmitate violet red micro-needles from C,H -MeOH. M.p. 76°corr. 

Cationic polymerization of crotonaldehyde is less important than anionic polymerization. With (EtO)3Al or (i-PrO)3Al as initiators, rather unstable polymers were obtained [187] with H3PO4 and PCI5 only oil was formed [188]. Polymerization of crotonaldehyde can also be induced by high electric fields (several 10 V/cm) [189]. Field polymerization results in the growth of organic semiconducting micro needles with side-chain cross-linking and P —3... 

Grunfest, H., Sengstaken, R. W., Oettinger, W. H., and Gurry, R. W., 1950, Stainless steel micro-needle electrodes made by electrolytic pointing. Rev. Sci. Instru. 21(4) 360-361. 

McAllister DV, Allen MG, Prausnitz MR (2000) Micro-fabricated micro-needles for gene and dmg delivery. Ann Rev Biomed Eng 2 289-313... 

Medical devices such as fetal heart rate monitors, patient monitoring, life support devices, and pulse oximeters, are in everyday use around the globe. In future, the healthcare industry can expect to see many advanced medical devices in use nanoparticles, magnetic drug homing devices, micro-needles, and polymer capsules (Friend et al. 2011). 

For SEM analysis, samples were redispersed into acetone and sonicated for 5 min. Then it was dropped on the microscopic Lam surface with micro-needle and dried at ambient temperature. All samples sputter coated... 

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