Dexamethasone release

Norton LW, Tegnell E, Toporek SS, Reichert WM. In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. Biomaterials 2005, 26, 3285-3297. 

Norton LW, Koschwanez HE, Wisniewski NA, Klitzman B, Reichert WM. Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Journal of Biomedical Materials Research. Part A 2007, 81, 858-869. 

Moussy and colleagues have also been involved in work with corticosteroids in animals with implanted devices. This group found that dexamethasone released from... 

Strecker EP Gabelmann A, Boos I, et al. Effect on intimal hyperplasia of dexamethasone released from coated metal stents compared with non-coated stents in canine femoral arteries. Cardiovasc Intervent Radiol 1998 21 487-496,... 

Figure 9.8 Release of dissolved dexamethasone from an EVAc matrix. The mass of dexamethasone released from a small polymer matrix ( 10 mg) during incubation in phosphate-buffered saline is plotted versus (a) time and (b) the square root of time. Data from [8].

Hanefeld P, Agarwal S, Kumar R, Greiner A. In vitro study of dexamethasone release from poly(p-xylylene) films. Macromol Chem Phys 2010 211(2) 265-9. 

Strecker, E.-P., Gabelmann, A., Boos, I., Lucas, C., Xu, Z., Haberstroh, J., Freudenberg, N., Strieker, H., Longer, M., and Betz, E., Effect on intimal hyperplasia of dexamethasone released from coated metal starts compared with non-coated stents in canine femoral arteries, Cardiovasc. Intervent. Radiol., 1998 21(6) 487-4%. 

Mishra et al. (2014) reported the release of dexamethasone from blood-compatible PURs and PUR-clay nanocomposites. They showed that PUR and PUR nanocomposite films did not induce platelet damage or aggregation in in vitro tests, thus displaying excellent blood compatibility. They were able to sustain dexamethasone release for up to 2 weeks depending on the polymer composition. PUR/clay nanocomposites possessed a slower release rate compared to pure PURs and were able to minimize the burst effect in the first hours of release. 

Yoon, J.J., Kim, J.H., Park, T.G., 2003. Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method. Biomaterials 24, 2323-2329. 

Zhong Y, McConnell GC, Ross JD (2005) A Novel Dexamethasone-releasing, Antiinflammatory Coating for Neural Implants. Presented at 2nd International IEEE EMBS Conference on Neural Engineering. 

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