Protein binding properties

Yu, M., Goldberg, S., Goldberg, A.L. (1W2). Heat shock in Escherichia coli alters the protein-binding properties of the chaperonin groEL by inducing its phosphorylation. Nature 357, 167-169. 

Casini, A., Cinellu, M.A., Minghetti, G., Gabbiani, C., Coronnello, M., Mini, E. and Messori, L. (2006) Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinudear gold(l II) compounds with bipyridyl ligands. Journal of Medicinal Chemistry, 49, 5524. 

M.-G. Baek and R. Roy, Synthesis and protein binding properties of T-antigen containing GlycoPAMAM dendrimers, Bioorg. Med. Chem., 10 (2002) 11-17. 

Returning once again to the questions of function and uses, the old concept of flavonoids being merely the by-products of cellular metabolism, which are simply compartmentalized in solution in the cell vacuole, is well and truly past its use-by date. For a start, studies have revealed that flavonoids are also commonly found on the outer surfaces of leaves and flowers, albeit only the aglycone form. Additionally, flavonoids have been shown over the past few years to be found in the cell wall, the cytoplasm, in oil bodies, and associated with the nucleus and cell proteins, as well as in the vacuole. Even in the vacuole, flavonoids are not necessarily found free in solution. For example, protein-bound flavonoids have been isolated from lisianthus and other flowers in which a structurally specific binding has been identified (in anthocyanic vacuolar inclusions). It is probable that flavonoid location and specific protein binding properties will ultimately prove to relate directly to their function in plants. 

Initially, conventional PCR tubes from various suppliers consisting, for example, of polypropylene or PVC with intentionally low proteinbinding capacities were used for IPCR [24, 29, 30, 41, 70]. As an alternative, polycarbonate TopYield modules (Nunc, Roskilde), specifically designed for IPCR applications with improved protein-binding properties, are increasingly popular as the material of choice for IPCR [26, 27, 34-37, 51, 62, 66, 67],... 

Kratz F, Keppler BK, Messori L, Smith C, Baker EN (1994) Protein-binding properties of two antitumour Ru(III) complexes to human apotransferrin and apolactoferrin. Met Based Drugs 1 169-173... 

Moghimi, S. M., and Szebeni, J. (2003), Stealth liposomes and long circulating nanoparticles Critical issues in pharmacokinetics, opsonization and protein-binding properties, Prog. Lipid Res., 42(6), 463-478. 

Polypropylene HPLC sample preparation, general filtration Good for both aqueous and organic samples. Has low protein-binding properties. +++ —... 

When the plasma protein binding properties of triamcinolone were studied it was found that tritium-labeled triamcinolone was present in the unbound state to a much greater extent than hydro- 0... 

Minimal nonspecific cellular and blood-protein binding properties. 

One of the ideal situations in the treatment of disease is the delivery of efficacious medication to the site of action in a controlled and continual manner at the appropriate concentration. Controlled-released, biodegradable nanoparticles that can be loaded with the appropriate drug products have been developed to treat conditions such as cancer, arthritis, and osteoporosis. In view of their low toxicity and their protein-binding properties, the nanoparticles may be useful in the oral administration of peptides, proteins, and oligonucleotides, especially for vaccination. 

Wang D, Liao W, Arora PS (2005) Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate application to Bcl-xL. Angew Chem Int Ed Engl 44(40) 6525-6529... 

The choice of available assays is narrower for free T3 and free T4 assays, and the measurements are more difficult because of the relatively low concentrations of these hormones therefore, these assays have been less commonly applied. Different methods for determining the free hormone levels include or omit extraction procedures. Direct methods, where free hormone is measured in the presence of bound hormone and proteins with free binding sites, can be problematic because the equilibrium between the free and bound fractions may be altered under the conditions of the assay. In addition, the different protein binding properties of different species may affect these analyses. Assays such as T3 uptake that estimated the available binding sites and protein bound iodide are largely obsolete. 

Memantine is a colorless to white crystalline substmice readily soluble in water. Its oral bioavailability is nearly 1(X)%. Memantine readily crosses the blood-brain barrier, and while in organism ii shows linear, dose-proportional pharmacokinetics and weak protein-binding properties. 

Greene, G., Radhakrishna, H. and Tannenbaum, R. 2005. Protein binding properties of surface-modified porous polyethylene membranes. Biomaterials 26 5972-5982. 

Fort and coworkers studied the aggregation and protein binding properties of amphiphilic rod-coil type of glycoconjugates (111 and 112, Fig. 19) synthesized using click chemistry between suitably functionalized precursors [109]. The glycan-functionalized amphiphiles were self-assembled in aqueous medium and their size and morphologies were dictated by the amphiphilic balance (volume fraction of... 

Smith, A. B., and Knowles, C. J., Potential role of a conducting polymer in biochemistry protein binding properties, Biotech. Appl. Biochem., 12, 661-669 (1990). 

Smith AB, Knowles CJ. Investigation of the relationship between conductivity and protein-binding properties of polypyrrole. J Appl Polym Sci 1991 43 399-403. 

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