Regulation of induction

Interestingly, Gassman and co-workers have demonstrated that the regulation of the induction of AHR by indolo[3,2-/)]carbazole (4) was reduced by prior activation of the hypoxia-inducible expression. As the hypoxia pathways are dependent on ARNT, prior activation may deplete the cell of available ARNT for AHR heterodimerization (97MI3). 

PP potentially harmful substances. PXR appears to be the key regulator of CYP3A induction by xenobiotics. 

Many of these compounds—puromycin and cycloheximide in particular—are not cfinically useful but have been important in elucidating the role of protein synthesis in the regulation of metabolic processes, particularly enzyme induction by hormones. 

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PALOZZA P, SERINI S, MAGGIANO N, ANGELINI M, BONINSEGNA A, DI NICUOLO F, RANELLETTI F O and CALVIELLO G (2002) Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by P-carotene through down-regulation of cyclin A and Bcl-2 family proteins , Carcinogenesis, 23, 11-18. 

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