Regulation internal factors

While these external and internal factors already provided a difficult foundation, a routine investigation into the company by the US Food Drug Administration (FDA) identified areas of non-compliance with Good Manufacturing Practice (GMP) regulations. The resulting... 

Kemp, W.M., and Boynton, W.R. (1981) External and internal factors regulating metabolic rates of an estuarine benthic community. Oecologia 51, 19-27. 

First let us consider regulation by internal factors, i.e. factors that are already present in the organism. In doing so we must distinguish between intracellular and intercellular regulation, as mentioned above. 

Up to now we have spoken only of regulation by internal factors. However, the situation within an organism is influenced quite substantially by external factors. Of the many external factors which can influence the growth and differentiation of plants, temperature and light are selected here. Moreover, we can point out only a few of the fundamentals relating to the mechanism of action of temperature and light in this section. 

Regulations and specifications. There may be international (e.g. EU), national or local regulations concerning the use of materials. These may be with respect to factors such as flammability, contact with foodstuffs, environmental considerations and medical criteria. 

Orsini MJ, Benovic JL (1998) Characterization of dominant negative arrestins that inhibit beta2-adreneigic receptor internalization by distinct mechanisms. J Biol Chem 273(51) 34616-34622 Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ (2006) Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. J Neurosci 26 9404-9412... 

All biological functions in an organism are interdependent and internally regulated and since their occurrence is context-dependent, they cannot be understood in isolation. Functional explanations are therefore more appropriate for understanding complex systems exhibiting many coupled interactions than are causal explanations which focus on a single factor. 

JOHNSON, C.S., SMYTH, D.R., The TTG2 gene of Arabidopsis encodes a WRKY family transcription factor that regulates trichome development and the production of pigment and mucilage in seed coats, 9th International Conference on Arabidopsis Research. 1998, 186. 

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