C/EBP family of transcription factors

Jiang, J. G., Zarnegar, R. (1997) A novel transcriptional regulatory region within the core promoter of the hepatocyte growth factor gene is responsible for its inducibility by cytokines via the C/EBP family of transcription factors. Mol... 

Three members of the C/EBP family of transcription factors are expressed in adipocytes a, p, and 5. The temporal expression of the three isoforms during 3T3-L1 differentiation suggests that the C/EBP genes are subject to exquisite regulatory controls. Numerous studies have shown that C/EBPP and C/EBP5 regulate the expression of... 

The C/EBP family of transcription factors, known for their involvement in IL-6 signal transduction (Kishimoto et al., 1994), participate together with STAT proteins in mediating CNTF-induced signal transduction (Symes et al., 1995). The existence of such combinatorial actions provides an explanation for differences in the actions of cytokines that activate common signal-transducing systems. 

CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcription factors that contain a basic leucine zipper domain at the C-terminus that is involved in... 

The CCAAT/enhancer-binding proteins (C/EBP) are transactivators known for their involvement in the regulation of acute phase and inflammatory protein expression [106]. The family comprises several isoforms, which can homo- and heterodimerize through their basic leucine zipper region [107], or associate with other transcription factors, including NF-kB [108, 109]. Activation of the C/EBP proteins involves their phosphorylation in a negative regulatory domain [110, 111]. In a similar manner to PU.l, some C/EBP family... 

Fig. 1.39. Examples for families of interacting transcription factors. The circles indicate groups of eucaryotic transcription factors that can form homo- and heterodimers amongst themselves. The intersection of the circle of the ATT family with the circle of the Jun family indicates possible heterodimerization between the two famihes. The members of the Jun family can form complexes with members of the Fos family and with the members of the ATT family. The Fos family is unique in that its members can not form homodimers, but must heterodimerize with members of the Jun family. C/EBP CCAAT/enhancer binding protein ATF activating transcription factor CRE-BP cAMP responsive element binding protein. After Lamb and McKnight (1992).

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