Recombinational repair

Rad54 Rad54p S. cerevisiae Possibly none Recombination repair [326] alters DNA topology in an ATP-dependent reaction [327] assists strand pairing [328], also alters chromatin structure [329-331]. 

Soares DG Escargueil AE, Poindessous V, Sarasin A, de Gramont A, Bonatto D, Henriques JA, Larsen AK. (2007) Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. Proc Natl Acad Sci USA 104 13062-13067. 

Importantly, the ERCCl/XPF structure-specific nuclease has an additional role in the repair of cisplatin adducts besides its function in NER the recombinational repair of interstrand crosslinks (19). ERCCl- or XPF-deficient hamster mutant cell lines are hypersensitive to DNA crosslink agents, much more so than to ultraviolet-induced pyrimide dimers, the classical substrates for NER (20,21). Moreover, co-localization of ERCCl foci and RAD51 foci in response to cisplatin treatment has recently been found and may represent recruitment of ERCCl/XPF to sites of recombination repair (22). Previous studies have shown that BRCAl, involved in homologous recombination repair, also plays a major role in the repair of cisplatin DNA damage (23). 

Recombination and recombinational repair recA Uracyl glycosylase ung... 

Encodes protein that inhibits cell division, possibly to allow time for DNA repair Encodes RecA protein, required for error-prone repair and recombinational repair Encodes DNA polymerase IV... 

Encodes subunit of integration host factor (IHF), involved in site-specific recombination, replication, transposition, regulation of gene expression Required for recombinational repair... 

As with photoreactivation, excision repair and recombination repair, the story starts with yet another form of reactivation of UV-irradiated phage in host cells. This phenomenon was first observed by Luria(1947), but came to be known as Weigle reactivation. He observed that UV-irradiated bacteriophageX survives better when plaqued on E. coli which has been previously irradiated with a small dose of UV (Weigle, 1953). This paper also showed that whatever repair process is induced in the host cells by these small doses of UV was mutagenic. For a time it came to be known as error-prone repair, distinguishing it from excision repair which was said to be error-free. The distinction was dramatically demonstrated by Howard-Flanders, who found that the rate of induction of mutation by UV was 100-1000-fold higher in strains of E. coli defective in excision repair. 

There are also data that indicate that aluminum does not directly interact with DNA in mutagenicity tests. These data come from negative transformation assays in Syrian hamster cells (DiPaolo and Casto 1979), negative rec (recombination repair) assays in Bacillus subtilis (Kanematsu et al. 1980), and negative Ames assays in Salmonella typhimurium (Marzin and Phi 1985). These data are summarized in Table 2-4. 

Replication and postreplication (recombination) repair believed to occur during semiconservative DNA replication. They are of considerable basic interest339 and are also used to some extent in screening tests.198... 

RECOMBINATIONAL REPAIR Repair by recombination between sister DNA molecules that fills the gaps opposite unrepaired lesions left in the daughter ENA strands after replication of damaged DNA. (See also POSTREPLICATION REPAIR)... 

Recombinational repair Double-strand breaks Requires sequence homology, DNA... 

The homologous recombination repair pathway is highly complex, in part perhaps as a consequence of the diverse collection of structures on which it acts. Many proteins have been implicated in this pathway, but their real specific roles in the... 

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