Receptor agonists/activators

Isoproterenol (104) is an important agent for classification because of its selective p-receptor agonist activity. It is of special interest that its chronotropic (increase in heart rate) and inotropic (increase in force of contraction) effects exceed that of epinephrine it is also used in the management of mild to moderate asthma due to its bronchodilating effect, resulting in increased vital capacity of the lungs. 

Test Systems Addressing 5-HT4 Receptor Agonist Activity 197... 

TEST SYSTEMS ADDRESSING 5-HT4 RECEPTOR AGONIST ACTIVITY... 

Ramelteon is a hypnotic with melatonin receptor agonist activity targeting melatonin MTj and MT2 receptors. It has not been proven to induce dependence. As with zolpidem and zaleplon, no known anxiolytic properties have been elicited. No appreciable activity on serotonin, dopamine, GABA, or acetylcholine is present with the parent compound, but in vitro studies report that its primary metabolite M-II has weak 5-HT2g receptor agonist activity. 

H3 Receptor Agonist Activity of Imidazole-methylated Histamine Derivatives... 

Nonaminergic Compounds with Partial H3 Receptor Agonist Activity... 

For DA2 receptor agonists, activity may be enhanced by the presence of a hydrophobic binding group at this site. For example, in N-(n-propyl)-N-2-phenethyl substituted compounds, the phenyl ring of the 2-phenethyl substituent could interact with this receptor feature. 

HT7 Receptor agonist activity of selected experimental agents was determined using standardized testing assays including ... 

Dynorphins are a class of endogenous opioid peptides produced by many different populahons of neurons. They function primarily as a K-opioid receptor agonist therefore, they may act as antidote against addiction to cocaine. However, they also have x- and 8-opiod receptor agonist activities. Dynophin A, which is a 17-residue peptide, and Dynophin B, which is a 13-residue pephde, are found in nature. 

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