Binding, hydrophobic

The magnitude of hydrophobic binding free energy has been estimated to be about 0.2 kJ mol per of host-guest contact. This positive contribution will of course be moderated by the loss of entropy on binding, reflecting the loss of translational and rotational freedoms of the separated components. 

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Zheng, Z.-H., Catano, A. R., Segelke, B.W., Stura, E.A., Peterson, P.A., Wilson, l.A. Crystal stmcture of mouse CDl an MHC-like fold with a large hydrophobic binding groove. Science 277 339-345, 1997. 

A series of bonded poly(alkyl aspartamide) coatings was prepared on silica by analogy to the method described above. Poly(succinimide) coating was reacted with n-alkyl- and arylalkylamines in dimethylformamide to yield a series of hydrophobic adsorbents. Poly(propyl aspartamide)-silica (PolyPROPYL A) showed the maximal reversible hydrophobic binding of hemoglobin among the Cl -C5... 

Collectively, these thermal denaturation studies demonstrated that aPNAs bind to complementary ssDNA targets with high affinity and in a sequence-specific manner consistent with our proposed base-pairing model. Additional electrostatic and hydrophobic binding interactions can be incorporated into the aPNA design without affecting the primary Watson-Crick binding mode. 

Figure 17.3 Anatomy of a redox enzyme representation of the X-ray crystallographic structure of Trametes versicolor laccase III (PDB file IKYA) [Bertrand et al., 2002]. The protein is represented in green lines and the Cu atoms are shown as gold spheres. Sugar moieties attached to the surface of the protein are shown in red. A molecule of 2,5-xyhdine that co-crystallized with the protein (shown in stick form in elemental colors) is thought to occupy the broad-specificity hydrophobic binding pocket where organic substrates ate oxidized by the enzyme. Electrons from substrate oxidation are passed to the mononuclear blue Cu center and then to the trinuclear Cu active site where O2 is reduced to H2O. (See color insert.)...

In addition, cyclodextrins, because of their hydrophobic cavity, are capable of hydrophobic binding of the diene and/or dienophile into the cyclodextrin cavity in water. Therefore, cyclodextrins with the... 

The importance of hydrophobic binding interactions in facilitating catalysis in enzyme reactions is well known. The impact of this phenomenon in the action of synthetic polymer catalysts for reactions such as described above is significant. A full investigation of a variety of monomeric and polymeric catalysts with nucleophilic sites is currently underway. They are being used to study the effect of polymer structure and morphology on catalytic activity in transacylation and other reactions. 

Jacobs RE, SH White. (1989). The nature of hydrophobic binding of small peptides at the bilayer interface Implications for the insertion of transbilayer helices. Biochemistry 28 3421-3437. 

A number of other structurally developed cyclodextrins have been synthesized. For example, hosts containing two hydrophobic binding sites, called duplex cyclodextrins, such as (273) (containing either a- or... 

It has already been mentioned that metal complexes with confined binding pockets often display unusual chemical reactivities (see Section II). Thus, complexes of substituted hydrotris (pyrazolyl)borates, in which the substituents serve to from a hydrophobic binding pocket, have already been shown to exhibit enhanced chemical reactivity when compared with their unmodified analogs (282,283). Likewise, cyclodextrin and calixarene-based metallocavitands have been used as catalysts for selective organic transformations, and even as catalysts for reactions that... 

The placement of four pyridyl groups on the upper rim of the resorcin[4]arene cavitands was followed by the addition of Pd(II) ions to generate a monomeric molecular receptor with hydrophobic binding sites <00TL3113>. The treatment of 2,4,6-rm[(4-pydrinyl)methyl-sulfanyl]-l,3,5-triazene (tpst) with silver to form a single-stranded one-dimensional coordination polymer, [Ag7(tpst)(C104)2(N03)5(dmf)2] , which contains nanotubes... 

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