Reactive oxygen species production

Cui, Y., Lu, Z., Bai, L., Shi, Z., Zhao, W.E., and Zhao, B. 2007. Beta-carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. EurJ Cancer 43 2590-2601. 

Serretti R, Core P, Muti S, Salaffi F. Influence of dichloromethylene dipho-sphonate on reactive oxygen species production by human neutrophils. Rheumatol Int 1993 13 135-138. 

Only a limited number of reliable prediction tools are currently available for photoinduced toxicity. This is not surprising since establishing phototoxic potential is a complex task. Phototoxicity can be the consequence of various mechanisms such as photogeneration of reactive oxygen species, production of toxic photoproducts or sensitization of DNA damage by energy transfer. In addition, so far, there are no available universal descriptors (indicators) to predict the photodynamic potency of chemicals. 

Lemaire, P. and Livingstone, D.R. (1997). Aromatic hydrocarbon quinone-mediated reactive oxygen species production in hepatic microsomes of the flounder Platichthys flesus L.). Comparative Biochemistry and Physiology, 117 131-139. 

Livingstone, D.R., Mitchelmore, C.L., O Hara, S.C.M., Lemaire, P, Sturbe, J., Forlin, L. (2000). Increased potential for NAD(P)H-dependent reactive oxygen species production of hepatic subcellular fractions of fish species with in vivo exposure to contaminants. Marine Environmental Research, 50 57-60. 

Niu, J., Profirovic, J., Pan, H., Vaiskunaite, R., and Voyno-Yasenetskaya, T. (2003). G Protein betagamma subunits stimulate pll4RhoGEF, a guanine nucleotide exchange factor for RhoA and Racl Regulation of cell shape and reactive oxygen species production. Circ. Res. 93, 848-856. 

Reactive oxygen species production is largely catalyzed by transition metals (especially copper and iron), and oxidative stress plays a critical role in AD pathogenesis. In one study, the association of metal levels and Ap toxicity was demonstrated by (i) the effect on cell viability by metal alone and in the combination with APP and Ap, (ii) Ap-induced neurotoxicity relevant to oxidative stress indicated by ROS production, and (iii) APPsw cells expressed APP and generated Ap, so that Ap Cu2+ and APP Cu2+ can catalyze more ROS generation than APP cells that only expressed APP. 

H9. Hendin, B. N., Kolettis, R N., Sharma, R. K., Thomas, A. J. J., and Agarwal, A., Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J. Urol. 161, 1831—1834 (1999). 

Ye, G., Metreveli, N. S., Ren, J., and Epstein, P. N. 2003. Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production. Diabetes 52 777-783. 

Inoguchi, T., P. Li, F. Umeda, H.Y. Yu, M. Kakimoto, M. Imamura, T. Aoki, T. Etoh, T. Hashimoto, M. Naruse, H. Sano, H. Utsumi, and H. Nawata. 2000. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49 1939-1945. 

Pias EK, Aw TY. 2002. Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production. FASEB J 16 781-790. 

Yatin SM, Varadarajan S, Butterfield DA (2000) Vitamin E Prevents Alzheimer s Amyloid beta-Peptide (l-42)-lnduced Neurontil Protein Oxidation and Reactive Oxygen Species Production. J Alzheimers Dis 2 123-131... 

In an in vitro study of the inhibitory effects of thiopental, midazolam, and ketamine on human neutrophil function, thiopental and midazolam inhibited chemotaxis, phagocytosis, and reactive oxygen species production at clinically relevant concentrations (48). Ketamine only impaired chemotaxis. These results may be relevant in guiding anesthetic drug therapy in septic patients. 

Figure 14. Schematic of reactive oxygen species production and cellular defense mechanisms (antioxidant enzymes catalase, SOD, GSH). Reactive oxygen species (ROS) production is detrimental for the cell. However, ROS, in small amounts and for short periods, can act as intermediates of cardioprotective signaling.

Livingstone, D.R. (2001) Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. Mar. Poll. Bull., 42, 656-666. 

Selivanov VA, Votyakova TV, Pivtoraiko VN, Zeak J, Sukhomlin T, Trucco M, Roca J, Cascante M (2011) Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol 7 el001115... 

Baier-Anderson, C. and R.S. Anderson. Chlorothalonil inhibits reactive oxygen species production, but not phagocytosis in fish (Morone saxatilus) phagocytes and oyster (Crassostrea virginica) hemocytes. Dev. Comp. Immunol. 21 127 1997. 

Rodrigues, C.M., Fan, G., Wong, P.Y., Kren, B.T., and Steer, C.J. (1998) Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Molecular Medicine, 4 (3), 165-178. 

The reactive oxygen species production, stimulated by PMA, essentially due to the activity of NADPH oxidase system, was adopted as cellular functional character in human HL-60 cell line. R.O.S. metabolism was studied by CL assay as described. Assays were performed in triplicates at 25 °C. CL system contained in 1.00 mL final volume with modified KRP solution 100 nmoles luminol, 1 x 10 cells without treatment (control) or treated with ATRA or monomers, in presence or absence of... 

Matsubara, M and Hasegawa, K, Benidipine, a dihydropyridine-calcium channel blocker, prevents lysophosphatidylcholine-induced injury and reactive oxygen species production in human aortic endothelial cells. Atherosclerosis 178 (2005) 57-66. 

Pan, M.H., Huang, Y.T., Ho, C.T., Chang, C.I., Hsu, PC., and Sun Pan, B. Indnction of apoptosis hy Meretrix lusoria throngh reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia cells. Life Sci 79 1140-1152, 2006. 

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