Meretrix lusoria

Tsai, J. S., Chen, J. L., and Pan, B. S. (2008). ACE-inhibitory peptides identified from the muscle protein hydrolysate of hard clam (Meretrix lusoria). Process Biochem. 43, 743-747. 

Firstly, Takagi and Simidu (25) examined the correlation between the organic acid content of 9 species of shellfish and their taste, and found that the more palatable species were not necessarily richer in succinic acid, as exemplified by the hard clam, Meretrix lusoria. These results led them to conclude that succinic acid does not dominate the delicious taste of shellfish. Secondly, Konosu et al. (26) reported that the succinic acid content of the short-necked clam, Tapes japonica, when determined immediately after collection, was very low (20-40 mg/100 g of edible part) as compared with Aoki s value (330 mg), and that the flavor of a fresh sample was as good as that of a commercially available sample that had accumulated a large amount of succinic acid. 

Key Words Antrodia cinnamomea apoptosis epidioxysterols functional food marine Meretrix lusoria nanoencapsulation. 

However, we finally found that the lectinlike component, the potential candidate for the tumor apoptosis-inducing principle, was unstable in its bioactivity from the fraction recovery process. Here, Pan et al. [14,15] (Figure 26.3) conducted a modified method for extraction from Meretrix lusoria and found that some epidioxysterol compounds [6] (Figure 26.4) showed strong antitumor/apoptosis-inducing ability. 

FIGURE 26.4 Structure of epidioxysterols (EDS) isolated from Meretrix lusoria. (Adapted from Pan, M.S., et ah, 2007, with permission.)... 

Pan, M.H., Huang, Y.T., Ho, C.T., Chang, C.I., Hsu, PC., and Sun Pan, B. Indnction of apoptosis hy Meretrix lusoria throngh reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia cells. Life Sci 79 1140-1152, 2006. 

K Shiomi, Y Kakehashi, H Yamanaka, T Kikuchi. Identification of arsenobetaine and a tetramethylarsonium salt in the clam Meretrix lusoria. Appl Organomet Chem 1 177-183, 1987. 

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