Nitric acid reaction with

Alkaloids of Pot Curare. This variety of curare is a dark brown, comparatively dry extract. According to Boehm, it contains protocurine, colourless hair-like needles, m.p. 306° (dec.), a base of low toxicity and yielding crystalline salts. A second alkaloid of similar type is protocuridine prisms, m.p. 274-6°, sparingly soluble in all ordinary solvents. The poisonous constituent is protocurarine, a red powder, easily soluble in water, and giving characteristic colour reactions with nitric acid and with oxidising agents in sulphuric acid, this latter reaction indicating a Strychnos spp. as a possible botanical source. 

Fluoroheptanoic acid, 46,37 from 2-fluoroheptyl acetate by reaction with nitric acid, 46,37 toxicity of, 46,38... 

Nitro-3,4,6-Tribromo-2-Naphthol (1-Nitio-3,4,6-tribromo-2-oxy-naphthalene). 02N.CloH3Br3.OH, mw 425.87, N 3.29%, OB toC02 -71.38%, turns black at 135°, mp 136° (decompn). Prepn from l,3,4,6 tetrabromo-l-nitro-2-naphthol by reaction with nitric acid, then alkali Ref Beil 6,655... 

In aromatic compds, an amino group may be replaced by the nitro group by diazotization and reaction with nitric acid in the presence of cuprous salts (the Sandmeyer reaction). This method is used for lab work only and is described in standard textbooks on preparative organic chemistry... 

The formation of chloramine as an intermediate, followed by reaction with nitric acid to produce the corresponding nitramine and HOC1, may explain the catalytic action of HC1 in the nitration of amines... 

The subsequent reaction of cyclohexane with air in the first step to adipic acid is not simple and, actually, is not well understood chemically. Only a small amount of cyclohexane present in the operation is allowed to react before the unreacted cyclohexane is recovered for recycle and the oxygen-containing products isolated for further reaction with nitric acid. Despite decades of research on this chemistry in efforts to increase yields and decrease by-product formation, substantial amounts of the starting cyclohex-... 

The effect of nitric acid on dimethyl sulphide in the presence of dioxan gives rise to a detonation, even at liquid nitrogen temperatures. There is no factor in this description that can prove whether the accident is related to sulphide or dioxan, which probably gives rise to dangerous reactions with nitric acid. 

Suter, C. M., Organic Chemistry of Sulfur, 111, London, Wiley, 1944 Reaction with nitric acid at a moderate temperature is explosive, dinitrogen oxide being evolved. 

It ignites on heating in chlorine, or in bromine or iodine vapours at higher temperatures. Reaction with nitric acid causes incandescence. 

Inductive effects can have very pronounced effects on the reactivity of amides and similar substrates towards nitrolysis. Chemists at the Naval Air Warfare Center (NAWC) have reported an extreme case encountered during the synthesis of the energetic 1,5-diazocine known as HNFX (86). A key step in this synthesis involves a very difficult nitrolysis of the electron deficient N-nosyl (4-nitrobenzenesulfonyl) bonds of (85). Nitrolysis with strong mixed acid requires a temperature of 70 °C for 6 weeks to achieve a yield of 16 %. The same reaction with nitric acid-triflic acid requires a temperature of 55 °C for 40 hours to achieve a 65 % yield of HNFX. The same chemists reported a similar case of N-nosyl bond nitrolysis which needed a nitrating agent composed of nitric acid-triflic acid-antimony pentafluoride. ... 

The nitrolysis of cyclic polyamides offers a possible alternative industrial synthesis of HMX. The nitrolysis of l,3,5,7-tetraacetyl-l,3,5,7-tetraazacyclooctane (TAT) (79) and 1,5-diacetyl-3,7-dinitro-l,3,5,7-tetraazacyclooctane (DADN) (80) with a solution of dinitrogen pentoxide in anhydrous nitric acid gives HMX in 79 % and 98 % yields, respectively. Interestingly, the same reactions with nitric acid-acetic anhydride fail at room temperature. 

Boyer and co-workers" also reported the synthesis of the guanidine tricycle (122), prepared as the tetrahydrochloride salt from the condensation of two equivalents of guanidine with 1,4-diformyl-2,3,5,6-tetrahydroxypiperazine in concentrated hydrochloric acid. Treatment of the tricycle (122) with absolute nitric acid yields thebis-nitrimine (123), whereas the same reaction with nitric acid-acetic anhydride yields HHTDD (117). 

Reaction with nitric acid liberates chlorine gas ... 

Reaction with nitric acid forms zirconium nitrate and with hydrochloric acid, zirconyl chloride, ZrOCb, is produced. 

Nitration of pyridines in other than nitric or sulfuric acids is of little interest here because either no reaction or N-nitration takes place (see Section 2.05.2.10). However, pyridine 1-oxide is considerably more reactive and treatment with benzoyl nitrate ultimately leads to the 3-nitro derivative (Scheme 25) (60CPB28). Annelation of a benzene ring bestows greater reactivity on the 3-position in quinoline, compared with pyridine, and reaction with nitric acid in acetic anhydride furnishes the 3-nitro derivative (ca. 6%) (Scheme 26). This isomer has also been obtained, again at low yield (6-10%), by treatment of quinoline with tetranitratotitanium(IV) in carbon tetrachloride (74JCS(P1)1751>. Nitration of benzo analogues of pyridine occurs much more readily in the benzene ring, and Chapter 2.06 should be consulted for these reactions. 

Condensation between the 4-amino group of the oxadiazole moiety of the triazolooxadiazolium inner salt 133 and formaldehyde furnished the methanediamino linked bis(inner salt) 92 from which the methanedinitroamine analogue 137 could be obtained on reaction with nitric acid (Scheme 20) <1995JHC1405>. 

Vigorous reaction with nitric acid, s.g. 1.40, e.g. at 80°C, for 2 hr, causes the substance (I) to undergo nitrolysis and nitration to form picric acid. 

Aliphatic hydrocarbons are seldom used separately due to their relatively sluggish reaction with nitric acid. The ignition capacity of hydrocarbons may be increased by dissolving in them aromatic amines or, as the Germans did in earlier experiments, vinyl ethers. 

The methanal and ammonia that split off the cage structure during the reaction with nitric acid need not be wasted. In the large-scale manufacture of cyclonite, a combination of nitric acid, ammonium nitrate, and ethanoic anhydride is used, which results in full utilization of the methanal and ammonia ... 

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