Rats, Sherman

Jarvis J.U.M. (1991). Reproduction of naked mole rats. In The Biology of the Naked Mole-Rat (Sherman P., Jarvis M. and Alexander R., eds.). Princeton University Press, pp. 384-325. [Pg.215]

Rat (Sherman) 4.5 mo (F) 1.62 (partially reversible decrease in the number of litters) Cannon and Ki mbrough... [Pg.70]

Rat (Sherman) Gd 7-14 1x/d (GO) 200 (increased mortality and liver Groce and neoplasms in offspring) Kimbrough 1984 ... [Pg.76]

Rat (Sherman) 8 mo (F) Hepatic 1.4 M 6.5 M (increased relative and absolute liver weight cytoplasmic vacuolation) Kimbrough et al. 1972 1260... [Pg.80]

Rat (Sherman) 129 d (F) 0.32 1.5 (15-24% decreased litter size, lipid accumulation in hepatocytes) Linder etal. 1974 1254... [Pg.90]

Rat Sherman and Fischer 4wk 24hr/d 25 (increased severity of infection by mycoplasma)... [Pg.46]

Six Sherman rats (gender not specified) were exposed to graded concentrations of aniline vapor for 4 h and observed for 14 d post-exposure (Carpenter et al. 1949). The concentration that killed approximately half of the rats (exact number not stated) was 250 ppm. Concentrations were based upon empirical calculation and were not measured. An 8-h exposure to 550 ppm killed 82% of an unreported number of rats (Comstock and Oberst 1952, as cited in Oberst et al. 1956). Methemoglobinemia was the only pathologic change cited no further details were reported. [Pg.43]

In a study by Fincke and Sherman (JL3), the calcium of spinach was not utilized as well as that from milk however, the calcium of kale, which is low in oxalic acid (3,4), was about as available as that from milk. The calcium utilization factor was determined by dividing the weight of calcium stored by the weight of calcium ingestion. Rats 4 weeks old were fed for 60 days a diet in which most of the calcium was supplied by skim milk, or in which half of the skim milk was replaced by dried spinach or dried kale in amounts to provide the same amount of calcium. The diets contained about 0.3% calcium and 10% butter fat. It was concluded that the poor utilization of the calcium of spinach was due to the oxalic acid in spinach. [Pg.107]

Dermal LDso values suggest that, irrespective of strain, female rats are more sensitive than male rats when disulfoton is administered dermally. The dermal LDso for disulfoton was determined to be 15.9 and 3.6 mg/kg in male and female Wistar rats, respectively (Mihail 1978). In Sherman rats, the dermal LDso was determined to be 15 and 6 mg/kg in males and females, respectively (Gaines 1969). In male Sprague-Dawley rats, the dermal LDso was determined to be 20 mg/kg (DuBois 1957). A dermal LDso value of 0.285 mL/kg (187 mg/kg) was reported for rats given a liquid formulation... [Pg.81]

For heptachlor dissolved in xylene and administered once, Gaines (1969) reported LDso values in Sherman rats of 195 mg/kg (males) and 250 mg/kg (females). Therefore, the dermal LD so for heptachlor in rats is between 195 and 250 mg/kg heptachlor (Ben-Dyke et al. 1970 Gaines 1969). The studies are limited by the lack of procedural details regarding the vehicle used for administration and the absence of data on the purity of the test compounds. [Pg.45]

LC50 (1-h inhalation) for rats >2,475ppm (Kennedy and Sherman, 1986). [Pg.462]

Kennedy and Sherman (1986) reported a NOEL value of 200 ppm for rats during a 90-d feeding period. [Pg.600]

Stula EF, Sherman H, Zapp JA Jr, et al. 1975. Experimental neoplasia in rats from oral administration of 3,3 -dichlorobenzidine, 4,4 -methylene-bis(2-chloroaniline), and 4,4 methylene-bis(2-methylaniline). Toxicol Appl Pharmacol 31 159-176. [Pg.165]

The dermal LD50 for 1,4-dichlorobenzene in Sherman rats was greater than 6,000 mg/kg/day (Gaines and Linder 1986). It is not clear how many rats died after dermal exposure to 1,4-dichlorobenzene in this study, and there are no toxicokinetic data that address the question of absorption of 1,4-dichlorobenzene by the dermal route. [Pg.102]

Honchar MP, Ackermann KE, Sherman WR Chronically administered lithium alters neither myo-inositol monophosphatase nor phosphoinositide levels in rat brain. J Neurochem 53 590-594, 1989... [Pg.661]

Kofman O, Sherman WR, Katz V, et al Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures. Psychopharmacology 10 229-234, 1993... [Pg.675]

Sheehan M, de Belleroche J Facilitation of GABA release by cholecystokinin and caerulein in rat cerebral cortex. Neuropeptides 3 429-434, 1983 Sherman AD, Petty F Additivity of neurochemical changes in learned helplessness and imipramine. Behav Neural Biol 35 344-353, 1982 Sherman WR Lithium and the phosphoinositide signaling system, in Lithium and the Cell. Edited by Birch NJ. London, Academic Press, 1991, pp 121-157 Sherman WR, Munsell LY, Gish BG, et al Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney, and testis. J Neurochem 44 798-807, 1985... [Pg.744]

Hepatocellular carcinomas and liver neoplastic nodules also increased in female Sherman rats gavaged with 100 mg/kg FireMaster FF-1 twice a week for two 3-week periods (12 total doses) separated by 10 weeks (Kimbrough et al. 1981). Following observation for 2 years, the incidence of carcinomas was 60.7%... [Pg.175]

Groce DF, Kimbrough RD. 1984. Stunted growth, increased mortality, and liver tumors of polybrominated biphenyl (PBB) dosed Sherman rats. J Toxicol Environ Health 14 695-706. [Pg.426]

Kimbrough RD, Groce DF, Korver MP, et al. 1981. Induction of liver tumors in female Sherman strain rats by polybrominated biphenyls. J Natl Cancer Inst 66(3) 535-542. [Pg.434]

Lee KP, Hebert RR, Sherman H, et al. 1975a. Bromine tissue residue and hepatotoxic effects of octabromobiphenyl in rats. Toxicol Appl Pharmacol 34 115-127. [Pg.437]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...