Rats, hematological parameters

Exposure to 782 ppm for 4 weeks caused an increase in platelet counts in male rats and an increase in total leukocyte count in female rats hematologic parameters did not change for mice or rabbits exposed to the same or higher concentrations. Despite its chemical similarity, ethyl benzene does not appear to cause the same damage to the hematopoietic system as benzene. ... 

Golbs S, Fuchs V, Leipner E, et al. 1978b. [Studies into effects of pesticide combinations on laboratory rats. 2nd communication Studies into action on selected hematological parameters and blood glucose]. Arch Exp Vet Med Leipzig 32. (German)... 

Siddiqui MKJ, Rahman MF, Anjum F, et al. 1987b. Effect of oral administration of endosulfan on some hematological parameters and serum enzymes in rats. Pesticides 21 25-27. 

Reductions of approximately 10% in total hemoglobin and mean cell hemoglobin were observed in rats receiving 1,000 mg/kg/day of MIL-H-83282LT for 4 weeks (Mattie et al. 1993). A 47% increase in white blood cell counts was also observed in this study. No effects on hematological parameters were seen in rats similarly exposed to MIL-H-83282 (Mattie et al. 1993). 

One study in Sprague-Dawley rats (10/sex/group) reported that feeding di- -octylphthalate at concentrations up to 5,000 ppm (350.1 or 402.9 mg/kg/day in males or females, respectively) for 13 weeks did not affect hematological parameters (Poon et al. 1995). 

Information regarding hematological effects in animals is scant. No hematologic effects (specific tests not provided) were observed in rats and rabbits exposed to 1,4-diehlorobenzene vapors at concentrations of 96 or 158 ppm, respectively, dosed for durations of 7 hours a day, 5 days a week for 5-7 months (Hollingsworth et al. 1956). A chronic-duration study reported that some changes in blood chemistry and hematologic parameters were seen in rats exposed 5 hours per day, 5 days per week to 1,4-dichlorobenzene at air concentrations of up to 490-499 ppm for 76 weeks however, the reported changes showed no consistent trend with dose, sex, or exposure duration that would indicate treatment-related effects (Riley et al. 1980). 

The effects of 1,4-dichlorobenzene ingestion on hematological parameters reported in both human and animal studies indicate that this is an area of potential concern for humans exposed to 1,4-dichlorobenzene. Possible effects in humans have been associated with red blood cells anomalies. Because of sex and species differences seen in animal studies (i.e., effects on red blood cells in rats and effects on... 

Experimental design Rats (7-13 male and 10-13 female) were exposed to 1,4-dichlorobenzene vapors for 7 hours a day, 5 days a week at concentrations of 0, 96, or 158 ppm for a total of 126-139 exposures. At the end of the exposure period, the animals were sacrificed, body and organ weights determined, and tissues examined microscopically. Hematology (parameters not specified), analysis of urine (blood, glucose, albumin, and sediment) and measurement of blood urea nitrogen were conducted for females exposed to the lowest concentration of 1,4-dichlorobenzene. 

No consistent alterations in hematological parameters (erythrocyte and total and differential leukocyte counts, hemoglobin levels, hematocrit, mean corpuscular volume) were observed in groups of male and female rats given chlorine dioxide in the drinking water for 90 days at concentrations that resulted in doses as high as 12 and 15 mg/kg/day for males and females, respectively (Daniel et al. 1990). 

Hematological Effects. No statistically significant differences in hematological parameters (erythrocyte count, hemoglobin, packed red cell volume) were seen compared to controls in hybrid rats (10 of each sex) exposed to up to 11.6 mg/m3 diazinon (nose-only) for 3 weeks, 5 days a week for 6 hours a day (Hartman 1990). 

Hematological parameters were normal in Sprague-Dawley rats (groups of 10-15 of each sex) receiving a single oral gavage dose of up to 528 mg/kg diazinon and examined 14 days later (Chow and Richter... 

Hematological. Based on a small number of studies, chlorobenzene may cause hematological changes. There were dose and time-related effects on red blood cell parameters, primarily an increase in reticulocyte count which increased in rats but not in rabbits exposed to vapors of chlorobenzene at concentrations > 75 ppm for 24 weeks (Dilley 1977). Other hematological parameters (red blood cell count, hemoglobins, hematocrit, and white blood cell count) were variable and were comparable to controls at the end of the test. Slight leukopenia and... 

Hematological Effects. Low serum potassium level was observed in a 22- year-old factory worker accidentally exposed by acute inhalation to barium carbonate powder (Shankle and Keane 1988). Altered hematological parameters were observed in rats following inhalation for an intermediate exposure period to 3.6 mg barium/m as barium carbonate dust (Tarasenko et al. 1977). Reported changes included decreased blood hemoglobin, decreased thrombocyte count, decreased blood glucose, decreased albumin, increased leukocyte count, and increased blood phosphorus. 

No changes in hematological parameters were observed in rats exposed to 15.5 mg chromium(IV)/m3 as chromium dioxide for 2 years (Lee et al. 1989). 

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