Rational approach to drug discovery

The foundation for the more rational approach to drug discovery that is practised today comes from basic research into disease processes and medical conditions. Much of this research is carried out in universities and other research institutions, with funding coming from both government and pharmaceutical industry sponsors. 

Eddershaw, P. J., Beresford, A. P., Bayliss, M. K., ADME/PK as part of a rational approach to drug discovery, Drug Discov. Today 2000, 5, 409-414. 

Following the Competition. When analyzing competitor s lead molecules published in the scientific or patent literature, the question to be asked is whether there are clear opportunities available for carving out new IP positions around novel SAR. This is a standard fast follow or "me too" rational design approach to drug discovery and optimization a good example is described in the development of ranitidine (67). This is also covered in detail in other chapters. 

Wermuth CG. The impact of QSAR and CADD methods in drug discovery. In Holtje HD, Sippl W, eds. Rational Approaches to Drug Design. Barcelona Prous Science, 2001 3-20. 

In the past few deeades there has been a hiatus in the momentum of research and discovery of novel medicinal compounds . This particular trend in drug development perhaps is augmented due to two vital factors, namely first, strict empirical and rational approach to drug design and secondly, high standards of safety and therapeutic efficacy together with tremendous increased costs of research and development and finally the clinical trials. 

Knowled of individual enzymes and receptor-ligand interactions now provides the opportunity for a more directed approach to drug discovery and development. The rational mode of anti-microbial drug discovery has started to bear fhiit with the identification of small molecule inhibitors of the anthrax lethal factor, and the structure-guided discovery of a new inhibitor of RNA translation in bacteria. ... 

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