Rabbits nasal

Cremaschi et al. [39] investigated transepithelial pathways of eel calcitonin, corticotrophin, sucrose, and polyethylene glycol-4000 (PEG-4000) transport across the nasal epithelium using rabbit nasal mucosa mounted on Ussing chamber that was maintained at 27°C. The electrical parameters of the tissues were those of leaky epithelium that allow macromolecules to permeate paracellularly their observation was similar to the finding made by McMartin et al. [40] in which the authors described the nasal epithelium as leaky with... 

Ugwoke MI, Agu RU, Jorissen M, Augustijns P, Sciot R, Verbeke N, Kinget R 2000 Toxicological investigations of the effects carboxymethylcellulose on ciliary beat frequency of human nasal epithelial cells in primary suspension culture and in vivo on rabbit nasal mucosa. Int J Pharm 205 43-51. 

Ohtake K, Maeno T, Ueda H, Ogihara M, Natsume H, Morimoto Y (2003) Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium. Pharm Res 20 1838-1845. 

Cremaschi D, Rossetti C, Draghetti MT, Manzoni C, Aliverti V (1991) Active transport of polypeptides in rabbit nasal mucosa possible role in the sampling of potential antigens. Pflugers Arch 419 425 132. 

Cremaschi D, Porta C, Ghirardelli R (1996) The active transport of polypeptides in the rabbit nasal mucosa is supported by a specific vesicular transport inhibited by cytochalasin D. Biochim Biophys Acta 1283 101-105. 

Cremaschi D, Ghirardelli R, Porta C (1998) Relationship between polypeptide transcytosis and lymphoid tissue in the rabbit nasal mucosa. Biochim Biophys Acta 1369 287-294. 

Kubo H, Hosoya K, Natsume H, Sugibayashi K, Morimoto Y (1994) In vitro permeation of several model drugs across rabbit nasal mucosa. Int J Pharm 103 27-36. 

C. Porta, S. Dossena, V. Rossi, M. Pinza, and D. Cremaschi. Rabbit nasal mucosa Nanosphere coated polypeptides bound to specific anti-polypeptide IgG are better... 

Dahl, A.R. (1985) Mutagenicity of some dialkylnitrosamines, cyclic nitrosamines and N,N-di-ethanolnitrosamine in Salmonella typhimurium with rat and rabbit nasal, lung and liver S9 homogenates. Mw/at. Res., 158,141-147... 

Phosphatidylcholines 0.1%-0.5% Rabbit, rabbit nasal mucosa Insulin, growth hormone C, G, H 82, 83... 

Carstens, S., et al. 1993. Transport of insulin across rabbit nasal mucosa in vitro induced by didecanoyl-L-alpha-phosphatidylcholine. Diabetes 42 1032. 

Ding X., Porter T. D., Peng H.-M. and Coon M. J. (1991) cDNA and derived amino acid sequence of a rabbit nasal cytochrome p450NMB (p450IIGl), a unique isozyme possibly involved in olfaction. Arch. Biochem. Biophys. 285, 120-125. 

Since the concentrations of insulin to be administered in the sheep model would have been large, the insulin-loaded chitosan nanoparticles were not investigated in that model. However, the pharmacodynamics and pharmacokinetics of various insulin-chitosan preparations were compared with postloaded insulin-chitosan nanoparticles. It was found that chitosan solution and chitosan powder formulations were far better, with the chitosan powder formulation showing a bioavailability of 17% as against 1.3 and 3.6% for the chitosan nanoparticles and chitosan solution [72], The effects of the concentration and osmolarity of chitosan and the presence of absorption enhancers in the chitosan solution on the permeation of insulin across the rabbit nasal mucosa in vitro and in vivo were investigated, and the same... 

Diazepam As mentioned earlier, because of shortcomings of rectal administration, the nasal delivery of diazepam has gained interest. The nasal bioavailability of diazepam in sheep was estimated and further compared with results obtained earlier in humans and rabbits [106] in this study, human and rabbit nasal bioavailability for the first 30min was reported to be 37 and 54%, respectively [113]. Diazepam solubilized in PEG 300 was used for nasal administration via a modified nasal device, a Pfeiffer unit dose (Princeton, NJ). The sheep received the nasal formulations in a fixed standing position such that the head was slightly tilted back. It was found that the serum concentration after administration of a 7-mg solution of diazepam was... 

Ugwoke, M. I., Agu, R. U., Jorissen, M., Augustijns, P., Sciot, R., Verbeke, N., and Kinget, R. (2000), Nasal toxicological investigations of Carbopol 971P formulation of apomor-phine Effects on ciliary beat frequency of human nasal primary cell culture and in vivo on rabbit nasal mucosa, Eur. J. Pharm. Sci., 9, 387-396. 

Callens, C., Adriaens, E., Dierckens, K., and Remon, J. P. (2001),Toxicological evaluation of a bioadhesive nasal powder containing a starch and Carbopol 974 P on rabbit nasal mucosa and slug mucosa, J. Controlled Release, 76, 81-91. 

Ohtake, K. Maeno, T. Ueda, H. Natsume, H. Morimoto, Y. Poly-L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro. Pharm. Res. 2003,20 (2), 153-160. 

Bindseil E, Bechgaard E, Jorgensen L, Larsen R. Morphological examination of rabbit nasal mucosa after exposure to acetyl-salicylic acid, glycofurol 75 and ephedrine. Int ] Pharm 1995 119(1) 37 6. 

The rate of absorption of sulphur mustard across the human respiratory tract is unknown. Cameron et al. (1946) demonstrated that some 80% of inhaled mustard was removed by the rabbit nasal mucosa. The corresponding figure for nitrogen mustard was 90%. Absorbed sulphur mustard binds rapidly to protein and disappears from the circulation. 

Bechgaard, E., Gizurarson, S., Jorgensen, L., and Larsen R., 1992, The viability of isolated rabbit nasal mucosa in the Ussing chamber, and the permeability of insulin across the membrane, 7 r. J. Pharm. 87 125-132. 

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