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Rabbits and dogs

Asarum europeum L. According to Abdul menev, the root of this plant contains 1-7 per cent, of imcharacterised alkaloid, asarine. The root produces in frogs, rabbits and dogs, acceleration of respiration, nausea and emesis the cardiac activity of the leaves is thought to be due to a glucoside. (Farmatsiya, 1945, 8, No. 4, p. 39 Chem. Abstr., 1946, 40, 7411.)... [Pg.779]

There have been no reports of renal toxicity associated with acute inhalation exposure to endosulfan in laboratory animals. However, acute oral and dermal exposure to endosulfan has been reported to cause damage to the kidneys of rats, rabbits, and dogs (FMC 1958, 1980a Gupta and Chandra 1975 Hoechst... [Pg.152]

The iv toxicity of palytoxin is shown in Table I. Rabbits and dogs appear to be the sensitive to palytoxin rats and guinea pigs appear less sensitive. Table II shows the comparative toxicity of palytoxin administered by several routes - again iv palytoxin is extremely toxic while ir and po are relatively without toxic effects. [Pg.246]

To determine the toxicity of parathion to warmblooded animals, tests were made with mice, rats, guinea pigs, rabbits, and dogs. Greatest hazards are associated with insecticidal use, but symptoms of toxicity may be detected well in advance of severe toxic actions. [Pg.31]

Acute Toxicity. The LD50 following oral administration of parathion, either in propylene glycol solutions or in aqueous suspensions of the 15% wettable powder, has been determined for rats, mice, and guinea pigs. The lethal dose was approximated for rabbits and dogs. The results of these experiments are summarized in Table I. Statistical evaluation was by the method of Wilcoxon and Litchfield (11). [Pg.31]

Klaassen CD, Shoeman DW. 1974. Biliary excretion of lead in rats, rabbits, and dogs. Toxicol Appl Pharmacol l(9) 434-446. [Pg.539]

Nickel toxicity in rabbits and dogs demonstrated experimentally. High doses of nickel 1, 2, 4... [Pg.444]

Inhalation of nickel compounds other than nickel carbonyl causes significant effects in humans, rats, mice, rabbits, and dogs, with respiratory effects being most common. [Pg.499]

Dumaine, R. and Cordeiro, J.M. (2007) Comparison of K+ currents in cardiac Purkinje cells isolated from rabbit and dog. Journal of Molecular and Cellular Cardiology, 42, 378-389. [Pg.87]

Bakhtiar, R., Ramos, L., and Tse, F.L.S., Quantification of methylphenidate in rat, rabbit and dog plasma using a chiral liquid-chromatography/tandem mass spectrometry method. Application to toxicokinetic studies, Anal. Chim. Acta, 469, 261, 2002. [Pg.167]

Savini EC, Moulin MA, Herrou MFJ. (1971) Experimental study of the effects of quinine on the fetus of rats, rabbits, and dogs. Therapie 26 563-574. [Pg.264]

Concentrations near 30,000ppm were lethal to rats within 15 minutes toxic signs included loss of coordination and narcosis. This level of exposure produced pulmonary edema, and in cases of delayed deaths, there was interstitial pneumonitis. Concentrations as low as 3 000 ppm for 15 minutes produced light narcosis in rats. No toxic effects were observed in rats, rabbits, and dogs exposed 7 hours/day, 5 days/week for 14 weeks to... [Pg.149]

The toxicltles of repeated intravenous doses of I and II in rabbits and dogs have been estimated.54 Six rabbits were given I at 50 mg/kg 5 d/wk for 6 wk four rabbits were given II at the same dose on the same schedule. Three dogs were given I at 25 mg/kg b.l.d. 5... [Pg.273]

The toxic effects of 2-PAH I and III on rabbits and dogs, given Intravenous Injections 5 d/wk for 6-8 wk, have been evaluated. ... [Pg.276]

Nickel toxicity in rabbits and dogs demonstrated experimentally. High doses of nickel sulfate given by stomach gavage caused gastritis, convulsions, and death sublethal doses produced emaciation and conjunctivitis 1, 2, 4... [Pg.444]

No unexpected toxicity observed with rabbits and dogs up to 30-50 mg/kg... [Pg.453]

Methods for assessing sperm motility, morphology, and counts in the rat, rabbit and dog a consensus report. Reprod Toxicol, 10(3) 237-244. [Pg.160]

MPL Vaccine adjuvant Cardiovascular/respiratory function safety pharmacology study, repeat-dose toxicity in rat (up to 4wks—subcutaneous), rabbit and dog, reproduction (embryo-fetal studies in rat and rabbit) and 2 in vitro genotoxicity studies No adverse effects 40... [Pg.24]

A thesaurismotic reaction has been found in many organs, but particularly the spleen, in mice, rats, rabbits and dogs treated with polyvinyl pyrrolidone (lARC, 1979). [Pg.1185]

Cone, E.J., Darwin, W.D., Buchwald, W.F., Gorodetzky, C.W. Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dog, Drug Metab. Dispos. 1983, 11, 446-450. [Pg.233]

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