Quantitation automated solid phase extraction

R. A. Coe, L. S. DeCesare and J. W. Lee, Quantitation of efletirizine in human plasma and urine using automated solid-phase extraction and column-switching high-... [Pg.295]

Quantitative Bioanalysis—Automated Solid-Phase Extraction... [Pg.156]

H Huang, JR Kagel, DT Rossi. Automated solid-phase extraction workstations combined with quantitative bioanalytical LC/MS. J Pharm Biomed Anal 19 613-620, 1999. [Pg.212]

Kabra, P.M. Wall, J.H. Dimson, P. Automated solid-phase extraction and liquid chromatography for assay of cyclosporine in whole blood. Clin.Chem., 1987, 33, 2272-2274 Sangalli, L. Bonati, M. Reversed-phase high-performance liquid chromatography determination of cyclosporin in human blood. Ther.Drug Monit., 1987, 9, 353-357 Shibata, N. Minouchi, T. Hayashi, Y Ono, T. Shimakawa, H. Quantitative determination of cyclosporin A in whole blood and plasma by high performance liquid chromatography. Res.Commun. Chem.Pathol.Pharmacol., 1987, 57, 261-271... [Pg.456]

Schuster, A. Burzawa, S. Jemal, M. Loizillon, E. Couerbe, P. Whigan, D. Quantitative determination of the HIV protease inhibitor atazanavir (BMS-232632) in human plasma by liquid chromatography-tandem mass spectrometry following automated solid-phase extraction, J.Chromatogr.B, 2003, 788, 377-386. [Pg.59]

Wachs, T. and Henion, J. 2003. A device for automated direct sampling and quantitation from solid-phase sorbent extraction cards by electrospray tandem mass spectrometry. Anal. Chem. 75 1769. [Pg.243]

Pharmacokinetics Quantitative bioanalysis Selected ion monitoring Selected reaction monitoring Automated off-line solid-phase extraction Automated on-line extraction Fouda et al., 1991 Wang-Iverson et al., 1992 Covey et al., 1986 Kaye et al., 1992 Allanson et al., 1996 Simpson et al., 1998 Needham et al., 1998... [Pg.148]

Pommier F, Boschet F, Gosset G (2003) Quantitative determination of benazepril and benazeprilat in human plasma by gas chromatography-mass spectrometry using automated 96-well disk plate solid-phase extraction for sample preparation. J Chromatogr B 783 199-205... [Pg.635]

Wachs, T. Henion, J.A. Device for Automated Direct Sampling and Quantitation from Solid-Phase Sorbent Extraction Cards by Electrospray Tandem Mass Spectrometry, Anal. Chem. 75, 1769-1775 (2003). [Pg.225]

Jemal, M. Huang, M. Mao, Y. Whigan, D. Schuster, A. Liquid Chromatography/Electrospray Tandem Mass Spectrometry Method for the Quantitation of Fosinoprilat in Human Serum using Automated 96-Well Solid-Phase Extraction for Sample Preparation, Rapid Commun. Mass Spectrom. 14(12), 1023-1028 (2000). [Pg.507]

Zhang, L. Laycock, J.D. Hayos, J. Flynn, J. Yesionek, G. Miller, K.J. Automated Strategies for Protein Precipitation Filtration and Solid Phase Extraction (SPE) Optimization on the TECAN Robotic Sample Processor—Applications in Quantitative LC-MS/MS Bioanalysis, paper presented at LabAutomation 2004, February 1-5,2004, San Jose, CA. [Pg.535]

Chang, Y.-C., Li, C.-M., Li, L.-A., Jong, S.-B., Liao, P.C. and Chang, L.W. (2003). Quantitative measurement of male steroid hormones using automated on-line solid phase extraction liquid chromatography-tandem mass spectrometry and comparison with radioimmunoassay. Analyst, 128, 363-368. [Pg.29]

Jensen, B.H. Larsen, C. Quantitation of diltiazem in human plasma by HPLC using an end-capped reversed-phase column. Acta Pharm.Nord., 1991, 3, 179—180 Leneveu, A. Stheneur, A. Bousquet, A. Roux, A. Automated high-performance liquid chromatographic technique for determining diltiazem and its three main metabolites in serum. J.Liq.Chromatogr., 1991, 14, 3519-3530 [serum extracted metabolites SPE pharmacokinetics LOD 2.5 ng/mL] Bonnefous, J.L. Boulieu, R. Comparison of solid-phase extraction and liquid-liquid extraction methods for liquid chromatographic determination of diltiazem and its metabolites in plasma. [Pg.528]

H. Lindenblatt, E. Kramer, P. Holzmann-Erens, E. Gouzoulis-Mayfrank and K.-A. Kovar, Quantitation of psilocin in human plasma by high-performance liquid chromatography and electrochemical detection comparison of liquid-liquid extraction with automated on-line solid-phase extraction, J. Chromatogr. B, 1998, 709, 255-263. [Pg.210]

Principles and Characteristics As mentioned already (Section 3.5.2) solid-phase microextraction involves the use of a micro-fibre which is exposed to the analyte(s) for a prespecified time. GC-MS is an ideal detector after SPME extraction/injection for both qualitative and quantitative analysis. For SPME-GC analysis, the fibre is forced into the chromatography capillary injector, where the entire extraction is desorbed. A high linear flow-rate of the carrier gas along the fibre is essential to ensure complete desorption of the analytes. Because no solvent is injected, and the analytes are rapidly desorbed on to the column, minimum detection limits are improved and resolution is maintained. Online coupling of conventional fibre-based SPME coupled with GC is now becoming routine. Automated SPME takes the sample directly from bottle to gas chromatograph. Split/splitless, on-column and PTV injection are compatible with SPME. SPME can also be used very effectively for sample introduction to fast GC systems, provided that a dedicated injector is used for this purpose [69,70],... [Pg.437]

Direct injection of blood serum (102) or sample extracts with little or no cleanup (53) is possible, which makes HPLC procedures comparable in speed with other rapid tests With increased use of solid-phase absorption in cleanup, automation of procedures is feasible TLC is also a useful and inexpensive technique and quantitative TLC methods have been described (30,63) The following chapter describes practical application of various procedures in a drug residue monitoring program ... [Pg.164]

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