Psoriasis pathophysiology

Cyclosporine and tacrolimus are calcineurin inhibitors that are administered as part of immunosuppressive regimens in kidney, liver, heart, lung, and bone marrow transplant recipients. In addition, they are used in autoimmune disorders such as psoriasis and multiple sclerosis. The pathophysiologic mechanism for ARF is renal vascular vasoconstriction.41 It often occurs within the first 6 to 12 months of treatment, and can be reversible with dose reduction or drug discontinuation. Risk factors include high dose, elevated trough blood concentrations, increased age, and concomitant therapy with other nephrotoxic drugs.41 Cyclosporine and tacrolimus are extensively metabolized by... 

Describe the pathophysiology of psoriasis including types of psoriasis and clinical presentations. 

Based on the recent advances in our understanding of the pathogenesis and pathophysiology of psoriasis, there was... 

From West DP, West LE, Scuderi L, Micali G. Psoriasis. In DiPiro JT, Talbert RL, Yee GC, et al, (eds.) Pharmacotherapy A Pathophysiologic Approach. 6th ed. New York McGraw-Hill 2005 1 775, with permission. 

Alefacept (Amevive) is an immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 linked to the Fc portion of human IgGl. Alefacept interferes with lymphocyte activation, which plays a role in the pathophysiology of psoriasis, resulting in a reduction in subsets of CD2 T lymphocytes and circulating total CD4 and CD8 T lymphocyte counts. Alefacept is indicated for the treatment of... 

An accumulation of scales on the skin surface may be due to either an increased production of corneocytes, such as in psoriasis, or to a delayed desquamation. It may be predicted that conditions with delayed desquamation, once their pathophysiology on the molecular level is understood, will be highly informative with regard to the understanding of desquamation. Two such conditions are recessive X-linked ichthyosis (RXI) and lamellar ichthyosis. 

Lozano Garcia MC, Baca Garcia E. Psoriasis y tratamento conlitio un mecanismo fisiopatologico commun . [Psoriasis and lithium treatment a common pathophysiology .] Actas Esp Psiquiatr 2002 30(6) 400-3. 

Psoriasis and lithium treatment a common pathophysiology ) Actas Esp Psiquiatr 2002 30(6) 400-3. 

Causes of skin damage and/or eruptions are diverse and may alternatively be traced to damage, irritant or allergic reactions, an underlying pathophysiological condition, or an infection. Depending on the problem, the entire skin or only a small part of it may be involved. Moreover, disease may be manifest in one part of a tissue as a consequence of a biochemical abnormality in another. For instance, the cardinal expression of psoriasis is its thickened, silvery, malformed stratum comeum (psoriatic scale), but the disease actually results from maverick proliferation of keratinocytes in the germinal layer of the... 

IL)-8, which are believed to be important in the pathophysiology of psoriasis. All of these cytokines are important in the development of psoriasis and represent possible targets of biologic therapies. 

Gaspari, A.A. (2006) Innate and adaptive immunity and the pathophysiology of psoriasis. JonmoJ ofthe American Academy of Dermatology, 54, S67-80. 

Psoriatic patients frequently present with altered ser am urate levels, a disturbance which is commonly attributed to some changes in nucleoprotein metabolism directly linked to the pathological process of the skin lesions in fact, it is well known that an increased turnover rate of the epidermal cells (from the normal value of 27 days to 3-4 days only) is responsible for the psoriatic skin changes (Fitzpatrick and Haynes, 1980). To date, no tracer turnover studies with labelled uric acid have been reported in patients affected by psoriasis. We present here the metabolic results obtained with the aid of C-uric acid in a group of psoriatic patients with various degrees of severity of the disease. The aim of the study was to elucidate some pathophysiologic aspects of uric acid turnover in such clinical conditions. 

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