Pseudomonas aeruginosa bacterial activity

Protection of rats from devl. of Pseudomonas aeruginosa infections Activation of multiple effector pathwaye (Tcells, Bcells, macrophages) Protection of mice from devl. of C. albicans infection (macrophages) Polysaccharides as antineoplastic immunostimulators (NK cells) Proliferative responses of blood lymphocytes Protection of ginseng saponins of immunosuppression in mice Inhibition on bacterial endotoxin-induced embryolethality in rats Induction of neutrophil accumulation in mice... 

Tamarind fruits are reported to have anti-fungal and anti-bacterial properties (Ray and Majumdar, 1976, Guerin and Reveillere, 1984, Bibitha et al, 2002, Metwali, 2003, and John et al, 2004, all cited in (5)). According to Al-Fatimi and collaborators 11), in an agar diffusion assay, extracts from T. indica flowers showed antibacterial activity against four bacteria tested Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa). Antimicrobial activity of T. indica study has been attributed to lupeol (Ali et al, 1998, cited in 11)). 

It is noteworthy that, in contrast to mammalian systems, the majority of bacterial strains exhibited sufficient activity even when the cells were grown under non-optimized conditions. Since enzyme induction is still a largely empirical task, cells were grown on standard media in the absence of inducers. Furthermore, all attempts to induce epoxide hydrolase activity in Pseudomonas aeruginosa NCIMB 9571 and Pseudomonas oleovorans ATCC 29347 by growing the cells on an alkane (decane) or alkene (1-octene) as the sole carbon source failed [27]. 

It is semisynthetic derivative of kanamycin. It is active against gentamicin resistant organisms e.g. Pseudomonas aeruginosa, Klebsiella, E. coli and Proteus. It is resistant to bacterial aminoglycoside inactivating enzymes. 

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