Proton-transfer reaction mass spectrometry PTR-MS

Karl, T., Yeretzian, C., Jordan, A., and Lindinger, W. Dynamic measurements of partition coefficients using proton-transfer-reaction mass spectrometry (PTR-MS), Int. J. Mass Spectrom., 223-224 383-395, 2003. 

Lindinger, W., Fall, R., Karl, T.G. (2001) Environmental, food and medical applications of proton-transfer-reaction mass spectrometry (PTR-MS). Adv. Gas Phase Ion Chem. 4 1-48. 

However, the desire to reduce or even eliminate the required sample preparation has led to the development of newer techniques, such as proton-transfer-reaction mass spectrometry (PTR-MS) and selected ion flow tube mass spectrometry coupled with ion mobility spectrometry (MS-SIFT IMS). These techniques allow real-time measurements within a single second. This enables analysis of gas composition during technological processes, monitoring of indoor air, and investigation of VOCs emitted by living organisms. 

Zhan, X., Duan, J., Duan, Y. Recent developments of proton-transfer reaction mass spectrometry (PTR-MS) and its applications in medical research. Mass Spectrom. Rev. 32, 143-165 (2013)... 

The traditional equilibrium method of flavor release study mentioned above is extremely time consuming, and several weeks are commonly needed to obtain full release profiles of flavors from powders. Recently, thanks to the pioneering work of Dronen and Reineccius (2003), proton transfer reaction mass spectrometry (PTR-MS) has been used as a rapid analysis to measure the release time-courses of flavors from spray-dried powders. The PTR-MS method has been applied extensively to analyze the release kinetics of volatile organic compounds from roasted and ground coffee beans. The release profiles could then be mathematically analyzed by means of Equation 1.1 to obtain the release kinetic parameters, A and n (Mateus et al., 2007). 

ENVIRONMENTAL, EOOD AND MEDICAL APPLICATIONS OF PROTON-TRANSFER-REACTION MASS SPECTROMETRY (PTR-MS)... 

The development of proton-transfer-reaction mass spectrometry (PTR-MS) as a tool for the analysis of volatile organic compounds (VOCs) is described. PTR-MS is based on the rapid, non-dissociative transfer of protons from H30 to most common VOCs, but not to the principal gases in the air sample. Recent developments in the design of PTR-MS instruments allow detection of some VOCs in the parts per trillion by volume range. This sensitivity and the capability of PTR-MS instruments to be operated for extended periods in both laboratory and field settings has allowed exploration of many aspects of VOC analysis in environmental, food and medical applications. 

Anderson, G.M., M.L. Alexander, and R.B. Westerberg Vapor phase analysis of mainstream tobacco smoke by proton transfer reaction mass spectrometry (PTR-MS) 57th Tobacco Science Research Conference, Program Booklet and Abstracts, Vol. 57, Paper No. 8, 2003,... 

We have briefly mentioned the use of data on IMR in plasma modeling and for the understanding of interstellar molecular synthesis as well as of ionospheric chemistry, and we also want to point out the applications of IMR in various methods of chemical ionization. The most recent one, developed in our laboratory, namely proton-transfer reaction mass spectrometry (PTR-MS), allows for on-line monitoring of volatile organic compounds at levels as low as a few parts per trillion and is therefore applicable for environmental, food, and medical research involving investigations of fast metabolic and enzymatic processes. 

Recently, a variety of sulfijr- and selenium-bearing compounds were identified through the use of GC/MS techniques [51-53], element specific technique of gas chromatography with atomic emission detection (GC-AED) [54], and by proton-transfer-reaction mass spectrometry (PTR-MS)[55] in the breath of persons after the ingestion of garlic. 

Proton transfer reaction mass spectrometry (PTR-MS) is similar to other external ion source methods in that it utilizes an external discharge ion source to generate Bronsted acids which act as proton sources to react with the analytes, but not react with the components of air. The PTR-MS can be used as an onhne source for continuous monitoring of air samples and the method has recently been shown to be useful for the detection of TATP vapors [58]. Detection of TATP vapor was reported at ppb levels in experiments conducted using a discharge of water vapor or ammonia in the ion source, with ammonia giving better sensitivity. 

Proton transfer reaction mass spectrometry (PTR-MS) was first developed at the Institute of Ion Physics of Innsbruck University in the 1990s. Nowadays, PTR-MS is a well-developed and commercially available technique for the on-line monitoring of trace volatile organic compounds (VOCs) down to parts per trillion by volume (ppt) level. PTR-MS has some advantages such as rapid response, soft chemical ionization (Cl), absolute quantification, and high sensitivity. In general, a standard PTR-MS instrument consists of external ion source, drift tube, and mass analysis detection system. Figure... 

Lindinger,W., Hansel, A., Jordan,A. (1998) On-hne monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS)—medical appMcations, food control and environmental research. International Journal of Mass Spectrometry, 173,191-241. 

Shen, C.Y, Li, J.Q., Wang, Y.J., Wang, H.M., Han, H.Y, Chu, YN. (2010) Discrimination of isomers and isobars by varying the reduced-field across drift tube in proton-transfer-reaction mass spectrometry (PTR-MS). Inter-... 

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