Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Proton pump inhibitors actions

H2-receptor antagonists are drugs used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia however, their use has waned since the advent of the more effective proton pump inhibitors. [Pg.221]

Esomeprazole (Nexium) [Gastric Acid Inhibitor/Proton Pump Inhibitor] Uses Short-term (4-8 wk) for erosive esophagitis/GERD H. pylori Infxn in combo w/ antibiotics Action Proton pump inhibitor, gastric acid Dose Adults. GERD/erosive gastritis 20 0 mg/d PO x 4-8 wk 20 0 mg IV 10-30 min inf or >3 min IV push, 10 d max Maint 20 mg/d... [Pg.152]

Pantoprazole (Protonix) [Gastric Acid Suppressant/Proton Pump Inhibitor] Uses GERD, erosive gastritis, ZE synd, PUD Action Proton pump inhibitor Dose 40 mg/d PO do not crush/chew tabs 40 mg IV/d (not >3 mg/min, use Protonix filter) Caution [B, /-] Disp Tabs, inj SE Chest pain, anxiety, GI upset Interactions t Effects OF warfarin t effects of photosensitivity W/ St. John s wort X effects OF ketoconazole EMS t Effects of anticoagulants may affect glucose (hypoglycemia) OD Unlikely to cause life-threatening Sxs... [Pg.248]

Rabeprazole (AcipHex) [Antiulcer Agent/Proton Pump Inhibitor] Uses PUD, GERD, ZE H. pylori Action Proton pump inhibitor Dose 20 mg/d may T to 60 mg/d H. pylori 20 mg PO bid X 7 d (w/ amoxicillin and clarithromycin) do not crush/chew tabs Caution [B, /—] Disp Tabs SE HA, fatigue, GI upset Interactions t Effects OF cyclosporine, digoxin -1- effects OF ketoconazole EMS None OD May cause N, tach, dry mouth, and drowsiness symptomatic and supportive... [Pg.271]

Mechanism of Action A proton pump inhibitor that selectively Inhibits the parietal cell membrane enzyme system (hydrogen-potassium adenosine triphosphatase) or proton pump. Therapeutic Effect Suppresses gastric acid secretion. Pharmacokinetics ... [Pg.674]

Other proton pump inhibitors e.g., lansoprazole is more potent than omeprazole and has higher bioavailability, rapid onset of action and longer duration of action. Pantoprazole is the new H+K+ATPase inhibitor with similar properties and action to omeprazole. [Pg.265]

These agents are second generation proton pump inhibitors. Their mode of action is similar to omeprazole. Structural differences give more rapid absorption and greater bioavailability of lansoprazole. Lansoprazole has less effect on P-450 enzymes, while interaction with pantoprazole is insignificant. Lansoprazole has a significant antibacterial effect on Helicobacter pylori. [Pg.187]

Five proton pump inhibitors are available for clinical use omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole. All are substituted benzimidazoles that resemble H 2 antagonists in structure (Figure 62-3) but have a completely different mechanism of action. Omeprazole is a racemic mixture of R- and S-isomers. Esomeprazole is the S-isomer of omeprazole. All are available in oral formulations. Esomeprazole and pantoprazole are also available in intravenous formulations (Table 62-2). [Pg.1313]

From a pharmacokinetic perspective, proton pump inhibitors are ideal drugs they have a short serum half-life, they are concentrated and activated near their site of action, and they have a long duration of action. [Pg.1314]

Proton pump inhibitors (PPIs), eg, omeprazole, lansoprazole Irreversible blockade of H +, K+-ATPase pump in active parietal cells of stomach Long-lasting reduction of stimulated and nocturnal acid secretion Peptic ulcer, gastroesophageal reflux disease, erosive gastritis Half-lives much shorter than duration of action low toxicity reduction of stomach acid may reduce absorption of some drugs and increase that of others... [Pg.1331]

From a pharmacokinetic perspective, proton pump inhibitors are ideal drugs they have a short serum half-life, they are concentrated and activated near their site of action, and they have a long duration of action. In contrast to H2 antagonists, proton pump inhibitors inhibit both fasting and meal-stimulated secretion because they block the final common pathway of acid secretion, the proton pump. In standard doses, proton pump inhibitors inhibit 90-98% of 24-hour acid secretion. [Pg.1478]

Pharmaceutical inhibition of gastric acid output (proton pump inhibitor, H2 receptor blocker) may have beneficial effects when combined with an unprotected pancreatin preparation, not only by protection of enzymes during their gastric passage, but also by increasing duodenal pH and thereby improving enzymatic action. (Note that, in chronic pancreatitis, duodenal pH is lower due to impairment of pancreatic bicarbonate secretion, see above). [Pg.286]

Q14 Proton pump inhibitors, for example omeprazole, greatly reduce secretion of gastric acid by a direct inhibitory action on the proton pumps of the parietal cells, which secrete H+ into the stomach lumen. They are used alone or in combination with the eradication of H. pylori, generally for treatment of severe reflux disease. [Pg.276]

VECURONIUM PROTON PUMP INHIBITORS -LANSOPRAZOLE Possible t efficacy and adverse effects of vecuronium Unclear Altered duration of action. May need t recovery time... [Pg.505]

The reduction of pain and other symptoms due to peptic ulceration may be quite closely linked to the current effect of a drug on acid secretion, but the rate of healing and eventual disappearance of an ulcer is a slow process, determined in part by the extent and duration of gastric acid secretion suppression over several weeks. The clinical response of ulcer healing is therefore a consequence of the cumulative degree of acid inhibition. Proton pump inhibitors such as omeprazole bind irreversibly to the proton pump to suppress gastric acid secretion. The extent of inhibition is close to 100% and responses are related to cumulative effects, but the irreversible nature of the drug action means that schedule dependence is not observed. [Pg.309]


See other pages where Proton pump inhibitors actions is mentioned: [Pg.476]    [Pg.103]    [Pg.72]    [Pg.623]    [Pg.74]    [Pg.165]    [Pg.173]    [Pg.201]    [Pg.241]    [Pg.325]    [Pg.171]    [Pg.173]    [Pg.1073]    [Pg.264]    [Pg.22]    [Pg.74]    [Pg.165]    [Pg.173]    [Pg.201]    [Pg.241]    [Pg.248]    [Pg.325]    [Pg.15]    [Pg.10]    [Pg.23]    [Pg.88]    [Pg.65]    [Pg.630]    [Pg.2976]    [Pg.104]    [Pg.42]   
See also in sourсe #XX -- [ Pg.119 ]




SEARCH



Action inhibitors

Proton pump

Proton pump inhibitors

Pump action

© 2024 chempedia.info