Gastritis erosive

Salim, A.S. (1990a). Removing oxygen-derived free radicals stimulates healing of ethanol-induced erosive gastritis in the rat. Digestion 47, 24—28. 

Salim, A.S. (1990b). Sulphydryls protect patients against complications of erosive gastritis. Dig. Dis. Sci. 35, 1436-1437. 

Salim, A.S. (1992a). Role of sulfhydryl-containing agents in the healing of erosive gastritis and chronic gastric ulceration in the rat. J. Pharm. Sci. 81, 70-73. 

Gl effects Use caution in those intolerant to salicylate because of Gl irritation, and in gastric ulcers, peptic ulcer, mild diabetes, gout, erosive gastritis, or bleeding tendencies. Salsalate and choline salicylate may cause less Gl irritation than aspirin. 

Esomeprazole (Nexium) [Gastric Acid Inhibitor/Proton Pump Inhibitor] Uses Short-term (4-8 wk) for erosive esophagitis/GERD H. pylori Infxn in combo w/ antibiotics Action Proton pump inhibitor, gastric acid Dose Adults. GERD/erosive gastritis 20 0 mg/d PO x 4-8 wk 20 0 mg IV 10-30 min inf or >3 min IV push, 10 d max Maint 20 mg/d... 

Pantoprazole (Protonix) [Gastric Acid Suppressant/Proton Pump Inhibitor] Uses GERD, erosive gastritis, ZE synd, PUD Action Proton pump inhibitor Dose 40 mg/d PO do not crush/chew tabs 40 mg IV/d (not >3 mg/min, use Protonix filter) Caution [B, /-] Disp Tabs, inj SE Chest pain, anxiety, GI upset Interactions t Effects OF warfarin t effects of photosensitivity W/ St. John s wort X effects OF ketoconazole EMS t Effects of anticoagulants may affect glucose (hypoglycemia) OD Unlikely to cause life-threatening Sxs... 

Gastrointestinal Erosive gastritis, peptic ulceration PGE2-mediated suppression of gastric acid secretion, which helps maintain mucosal barrier and regulate microcirculation COX-1... 

GIT Acute erosive gastritis and haemorrhage. Peptic ulcer risk is increased. 

Proton pump inhibitors (PPIs), eg, omeprazole, lansoprazole Irreversible blockade of H +, K+-ATPase pump in active parietal cells of stomach Long-lasting reduction of stimulated and nocturnal acid secretion Peptic ulcer, gastroesophageal reflux disease, erosive gastritis Half-lives much shorter than duration of action low toxicity reduction of stomach acid may reduce absorption of some drugs and increase that of others... 

Antral or prepyloric ulcers and erosive gastritis were identified after 12 of 84 courses of interleukin-4 in 72 patients, of whom three suffered from life-threatening bleeding. There were no treatment-related deaths and no clear correlation with the dose of interleukin-4. A possible protective effect of interleukin-2 on the... 

Notably, there is a poor correlation between GI ulceration and GI symptoms, with 50% of dyspeptic patients having a normal-appearing mucosa, and 40% of asymptomatic persons having endoscopically evident erosive gastritis. Approximately 80% of those who develop serious GI complications have no preceding dyspepsia. The ACR... 

GI hemorrhage, and erosive gastritis. These effects occur primarily with aspirin. Because nonacetylated salicylates lack the ability to acetylate COX and thereby irreversibly inhibit its activity, they are weaker inhibitors than aspirin. 

Mann, N. S., 1977, Capsaicin-induced acute erosive gastritis its prevention by antacid, metiamide, and cimetidine,/. K. Med. Assoc. 75 71-73. 

Fig. 2.1a,b. Erosive Gastritis. Double Contrast barium study (a) showing multiple erosions in the body and antrum of the stomach. Note the typical round lucencies with a central pit of barium. Endoscopy (b) confirms the small bulbous elevations with central ulcerations... 

Fig. 5.2a,b. Erosive gastritis double-contrast barium meal studies in two different patients demonstrating erosive gastritis involving the antrum (a) and the entire stomach (b)... 

In the absence of pre-existing peptic ulceration, major bleeding from aspirin is usually associated with acute haemorrhagic erosive gastritis (91, 92, 94 ). 

Acute haemorrhagic erosive gastritis was diagnosed by endoscopy in 74 of 400 consecutive patients admitted with upper gastrointestinal haemorrhage. A history of antecedent consumption of salicylate ingestion was obtained in 47%. In some cases there were associated gastric ulcers, sometimes multiple (92 ). 

Reynolds, K. W. (1974) Erosive gastritis with special reference to the role of aspirin and bile. Ann. Roy. Coll Surg. Engl, 55, 213. 

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