Analysis protocol

Verbal Protocol Analysis Technique in which the person is asked to give a "self-commentary" as he or she imdertakes a task. 

Protocol analysis. Protocol analysis is the process of capturing, decoding, and interpreting electronic traffic. The protocol analysis method of network intrusion detection involves the analysis of data captured during transactions between two or more systems or devices, and the evaluation of these data to identify unusual activity and potential problems. Once a problem is isolated and recorded, problems or potential threats can be linked to pieces of hardware or software. Sophisticated protocol analysis will also provide statistics and trend information on the captured traffic. 

In general, it is advantageous to demonstrate a lack of sensitivity of the principle trials results to alternative choices of the set of subjects analysed. In confirmatory trials it is usually appropriate to plan to conduct both an analysis of the full analysis set and a per-protocol analysis, so that any differences between them can be the subject of explicit discussion and interpretation. ... 

One very simplistic way of handling missing data is to remove those patients with missing data from the analysis in a complete cases analysis or completers analysis. By definition this will be a per-protocol analysis which will omit all patients who do not provide a measure on the primary endpoint and will of course be subject to bias. Such an analysis may well be acceptable in an exploratory setting where we may be looking to get some idea of the treatment effect if every subject were to follow the protocol perfectly, but it would not be acceptable in a confirmatory setting as a primary analysis. 

It must be noted, however, that even if the sample size calculation gives enough power for the per-protocol analysis the potential for bias in that analysis still remains. 

In a non-inferiority trial, the full analysis set and the per-protocol analysis set have equal importance and their use should lead to similar conclusions for a robust interpretation. ... 

Basic Protocol Analysis of P-Glucan in Cereal Flours and P-Glucan Concentrates E3.5.1... 

Alternate Protocol Analysis of Fresh Meat Surface Color Using Colorimetry F3.3.5... 

Ericsson KA, Simon HA. Protocol Analysis Verbal Reports as Data. Cambridge, MA MIT Press, 1993. 

In last years a neural network techniques have been applied and investigated for intrusion detection [7]-[10], Such approaches are based on different strategies. So, one of them for anomaly detection use analysis of the audit records, produced by the operating system [8]. The other one is based on network protocol analysis [9],... 

Key words Traceability Protocol analysis Reference Material Uncertainty... 

Safety analysis patient set was defined as all patients who received the Biod/VTs/o Batimastat OC stent, per-protocol analysis patient set was defined as all patients in the Safety analysis set who did not deviate from the protocol. Categorical variables were summarized using counts and percentages. Continuous variables were summarized using mean, standard deviation, minimum and maximum, and median for variable not showing a normal distribution. For comparison of subgroups, the unpaired two-tailed student s t-test was used. Results were considered statistically significant at P< 0.05. 

In contrast to the conservative ITT analysis, analysis of the per-protocol population may maximize the opportunity to demonstrate efficacy the per-protocol population is the population in which the treatment is likely to perform best. Adherence to the protocol may be related to the treatment and outcome (Kay, 2005). This is why the per-protocol analysis is considered secondary to the more conservative ITT analysis. 

If the picture painted by both the ITT analysis and the per-protocol analysis is similar, overall confidence in the trial results is increased. However, if they are... 

The starting point presides over the choice of the final analytical protocol. Analysis in biological samples for pharmacokinetic purposes poses limited difficulties because the determination of paclitaxel in human blood is rather straightforward. In contrast, analysis of plant samples deals with samples containing lesser quantities of a complex mixture of several taxanes. Separation and identification is thus a real challenge for the chromatographer. 

The assessment of PSE is in many ways parallel to a protocol analysis, with the important exception that the individual does not talk aloud about what he or she is doing. One of the strongest criticisms of protocol analysis is that being required to talk steadily about what one is doing potentially breaks an individual s train of thought. Moreover, there is some question about the accuracy of think-aloud protocols. An individual may not be aware of what he is doing and thinking (Nisbett Wilson, 1977). 

The goal of HP drug therapy is eradication of the organism. Treatment shonld be effective, well-tolerated, easy to comply with, and cost-effective. HP regimens should have eradication (cure) rates of at least 80% based on intention-to-treat analysis, or at least 90% based on per protocol analysis, and should minimize the potential for antimicrobial resistance. The use of a single antibiotic, bismuth salt, or antiulcer drug does not achieve this goal. However,... 

Table 3.5 PTP Pivotal study Part 1, Pharmacokinetics per-protocol analysis (n = 30) [25]...

For the per-protocol analysis population of 11 patients, the mean plasma half-life was 10.48 1.6 h, and adjusted recovery 2.0 0.5 lU dL plasma per lU kg body weight infused. These data are consistent with those seen in adolescents and older patients, when the greater weight-adjusted plasma volumes that affect the volume of distribution and adjusted recovery in young children, as well as potentially alter halflife, are taken into account [32]. 

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