Proteomic patterns

E.F. Petricoin and L.A. Liotta, SELDI-TOF-based serum proteomic pattern diagnostics for early detection of cancer. Curr. Opin. Biotech. 15, 24-30 (2004). 

Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C, Fishman DA, Kohn EC, Liotta LA (2002) Use of proteomic patterns in serum to identify ovarian cancer. Lancet 359 572-577... 

Yu LR, Zhou M, Conrads TP, Veenstra TD. Diagnostic proteomics Serum proteomic patterns for the detection of early stage cancers. Dis Marker 2003 19(4-5) 209-218. 

With the use of modem very sensitive analytical methods (especially with the possibility to enhance low-expressed proteins), the concept of substantial equivalence, coined years ago, of GMO to conventional counterparts may not have the same impact as at its origin. With proteomics patterns focusing on low-abundance species, the equivalence may never be demonstrated due to the plasticity of protein expression and their interdependence. It is clear today that the effects of transgenesis on transcriptome do not suffice to predict the modifications in proteomes and consequently in metabolomes (72). Needless to say, with CPLLs, many more modifications would be detected due to the capability to reach very low-expressed proteins. 

Yang SY, Xiao XY, Zhang WG, Zhang LJ, Zhang W, Zhou B, et al. Application of serum SELDI proteomic patterns in diagnosis of lung cancer. BMC Cancer 2005 5 83. 

Skvortsov S, Sarg B, Loeffler-Ragg J, Skvortsova I, Lindner H, Werner Ott H, et al. Different proteome pattern of epidermal growth factor receptor-positive colorectal cancer cell lines that are responsive and nonresponsive to C225 antibody treatment. Mol Cancer Ther 2004 3(12) 1551-1558. 

Veenstra TD, Prieto DA, Conrads TP (2004) Proteomic patterns for early cancer detection. Drug Discovery Today 9 889-897... 

Paweletz CP, Trock B, Pennanen M, Tsangaris T, Magnant C, Liotta LA, Petricoin EF 3rd (2001) Proteomic patterns of nipple aspirate fluids obtained by SELDI-TOF potential for new biomarkers to aid in the diagnosis of breast cancer. Dis Markers 17 301-7... 

Velassco, A., Trucco, C., Wiegand, L., Wood, K., et al. (2002a). Serum proteomic patterns for detection of prostate cancer. J. Natl. Cancer Inst. 94, 1576-1578. 

Use of proteomic patterns in serum to identify ovarian cancer. Lancet 359, 572-577. 

Nadae, S.,et al. (2003). Proteomic patterns of tumour subsets in non-small-ceU lung cancer. Lancet 362, 433 39. 

Recent comparison of gene expression profiles of von Hippel-lindau-i- versus von Hippel-lindau-ceU lines obtained from the clear cell RCC subtype identified proteins that might serve as candidate molecular markers. Inactivation of VHL is a hallmark in most sporadic clear cell RCC and it occurs early in renal carcinogenesis (Skates and Iliopoulus., 2004 Latifet al, 1993). Furthermore, the profile of secreted proteins could be directly AQ4 determined by analyzing comparatively the genomic and proteomic patterns of these cell lines as well as their conditioned tissue culture supernatants (Ferguson et al, 2004). A combination of cDNA microarray and proteome analyses appears reasonable since not every difference at the transcriptome level will translate into differences at the protein level, whereas posttranscriptional/posttranslational modifications were not detectable by tran-scriptomics. 

Veenstra, T.D. Cancer diagnosis using proteomic patterns. 32. Expert Rev. Mol. Diagn. 2003, 5 (4), 411-420. 

Z. Xiao, DaRue Prieta, T.P. Conrads, T.D. Veenstra, H.J. Issaq, Proteomic patterns their potential for disease diagnosis. Mol. Cell. Endocrin., 230 (2005) 95. 

Petricoin EF, Rajapaske V, Herman EH, Arekani AM, Ross S, Johann D, Knapton A, Zhang J, Hitt BA, Conrads TP, Veenstra TD, Liotta LA, Sistare FD. Toxicoproteomics Seram proteomic pattern diagnostics for early detection of drag induced cardiac toxicities and cardioprotection. Toxicol Pathol 2004 32 (Suppl l) 122-30. 

Petricoin EF, III. Ornstein DK, Paweletz CP, Ardekani A, Hackett PS, Hitt BA, Velassco A, Trucco C, Wiegand L, Wood K, Simone CB, I. cvinc PJ, Linehan WM, Emmert-Buck MR, Steinberg SM, Kohn EC, Liotta LA. Serum proteomic patterns for detection of prostate cancer. J Natl Cancer Inst 2002 94(20) 1576-8. 

Diamandis EP. Proteomic patterns in serum and identification of ovarian cancer. Lancet 2002 ... 

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