Proteomics proteome

Perhaps the biggest increase in the application and development of the MDLC technique since Cortes s book is in life sciences, which accounts for approximately half of this book. One reason for this may be due to the high level of interest in studying the human proteome (proteomics). Proteomics is such a demanding application that the separating power needed to resolve even the normal proteins in the body is so demanding that maximum separation power is needed to provide this capability. Many aspects of separations in proteomics are discussed in Chapters 9-13, 15 and 16. Chapter 14 discusses enantiomeric compound separations by MDLC. 

He, Q.Y., Chen, J., Kung, H.F., Yuen, A.P., Chiu, J.F. (2004). Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by, proteomics. Proteomics 4,... 

Essader, A.S., Cargile, B.J., Bundy, J.L., Stephenson, J.L., Jr. (2005). A comparison of immobilized pH gradient isoelectric focusing and strong-cation-exchange chromatography as a first dimension in shotgun proteomics. Proteomics 5, 24—34. 

Jang, J.H., and Hanash, S. (2003) Profiling of the cell surface proteome. Proteomics 3, 1947-1954. 

M. Scigelova and A. Makarov. Orbitrap Mass Analyzer Overview and Applications in Proteomics. Proteomics, 6(2006) 16-21. 

A. Gorg, W. Weiss, and M. J. Dunn. Current Two-Dimensional Electrophoresis Technology for Proteomics. Proteomics, 4(2004) 3665-3685. 

The application of the improved MS techniques presented above with highly resolving separation methods, such as 2-D electrophoresis, capillary HPLC, and CE, resulted in the creation of a new science, proteomics63 While genomics, described by DNA databases, represents the ground stage of the cell, the study of the differential status of the cell, due to various stimuli or disease states, reflects the functional expression of protein products or proteomics. Proteomics studies are aimed at identifying the proteome, the network of proteins that define the... 

Gorg A, Weiss W, Dunn MJ. (2004) Current two-dimensional electrophoresis technology for proteomics. Proteomics 4, 3665-85. 

Fields, S., Proteomics. Proteomics in geno-meland. Science, 2001. 291(5507) 1221. ... 

Schmid, D. G., Grosche, P., Bandel, H., and Jung, G. (2000). FTICR-mass spectrometry for high-resolution analysis in combinatorial chemistry. Biotechnol. Bioeng. 71 149-161. Scigelova, M., and Makarov, A. (2006). Orbitrap mass analyzer—Overview and applications in proteomics. Proteomics 6 (Suppl. 2) 16-21. 

Pieper R, Su Q, Gatlin CL, Huang ST, Anderson NL, Steiner S. Multi-component immunoaffinity subtraction chromatography An innovative step towards a comprehensive survey of the human plasma proteome. Proteomics 2003 3(4) 422 132. 

Reinders, J., Lewandrowski, U., Moebius, J. et al. (2004) Challenges in mass spectrometry-based proteomics. Proteomics, 4, 3686-703. 

Minimizing resolution of isotopically coded peptides in comparative proteomics. /. Proteome Res. 1,139-147. 

Hendriks MM, Smit S, Akkermans WL, Reijmers TH, EUers PH, et al. (2007) How to distinguish healthy from diseased Classification strategy for mass spectrometry-based clinical proteomics. Proteomics 7(20) 3672-3680... 

Proteomics proteome functional predictions from primary structure. See Norin, M. 

Proteomics proteomics, where mass spectrometry analyzes peptides derived from... 

Zahedi, R.P., Meisinger, C. and Sickmann, A. (2005) Two-dimensional benzyldimethyl- -hexadecylammonium chloride/SDS-PAGE for membrane proteomics. Proteomics 5,3581-3588. 

J. Reinders, U. Lewandrowski, J. Moebius, Y. Wagner, A. Sickmann, Challenges in MS-based proteomics, Proteomics, 4 (2004) 3686. 

Vitorino R, Lobo MJ, Ferrer-Correira AJ, Dubin JR, Tomer KB, Domingues PM, Amado FM. Identification of human whole saliva protein components using proteomics. Proteomics 2004 4(4) 1109-15. 

Koy C, Miklcat S, Raptakis E, Sutton C, Resch M, Tanaka K, Glocker MO. Matrix-assisted laser desorp-tion/ionization-quadrupole ion trap-time of flight mass spectrometry sequencing resolves structures of unidentified peptides obtained by in-gel tryptic digestion of haptoglobin derivatives from human plasma proteomes. Proteomics. 2003 Jun 3(6) 851-8. 

Wingren, C. Steinhauer, C. Ingvarsson, J. Persson, E. Larsson, K. Borrebaeck, C. A., Microarrays based on affinity-tagged single-chain fv antibodies Sensitive detection of analyte in complex proteomes, Proteomics 2005, 5, 1281-1291... 

Peng, J., Elias, J.E., Thoreen, C.C., Licklider, L.J., and Gygi, S.P. 2003. Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis The yeast proteome. /. Proteome Res. 2, 43-50. 

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