FTICR mass spectrometry

Octadecyl sulfate sodium salt (Ci8H37-0-S03 Na+) was examined by laser desorption (LD) Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) in the negative mode resulting in [M - H] ions. Little fragmentation was observed under these conditions [28]. 

The development of mass spectrometric techniques, such as fast atom bombardment mass spectrometry (FAB-MS), ° ° Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS), ° and tandem mass spectrometry (MS"), ° allowed enantiodiscrimination of chiral ion-dipole complexes the gas phase. These techniques and others will be illustrated in detail in the next Section 3. 

In 1974, Comarisov and Marshall60 developed Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). This technique allows mass spectrometric measurements at ultrahigh mass resolution (R = 100000-1000000), which is higher than that of any other type of mass spectrometer and has the highest mass accuracy at attomole detection limits. FTICR-MS is applied today together with soft ionization techniques, such as nano ESI (electrospray ionization) or MALDI (matrix assisted laser/desorption ionization) sources. 

The on-line interfacing of capillary isoelectric focusing with Fourier-transform ion cyclotron resonance-mass spectrometry (FTICR-MS) was shown to be effective for separating minor components of protein mixtures for on-line mass spectral analysis [62-64],... 

The nature of the vaporized ILs was a topic of some controversy until a follow up study was published [126], Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) was used at distillation conditions (4.0 x 10 6-1.3 x 10 5 mbar, > 200 °C). Aprotic IL vapors were found to be made up of neutral ion pairs, not free ions or clusters (neutral or ionic). It was also confirmed that protic IL vapors consisted of neutral molecules resulting from cation to anion proton transfer. Several studies have suggested that IL volatility is likely related to the extent of ion pairing present in the liquid phase [123, 127],... 

Figure 2.8 The principle of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS).

Recently introduced tandem mass spectrometers, having both features, such as quad-rupole linear ion trap (QqLIT, LTQ or Q-trap), quadrupole time-of-fiight (QqTOF), LTQ-Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS), and LTQ-Orbitrap, and so on, have allowed for the development of several new methods for acrylamide detection [107,108]. 

The laser-based optical and chemical imager (LOCI) is a unique instrument that combines accurate isotope ratio analyses obtained both by laser desorption Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and by LIBS without any sample preparation (Scott and Mcjunkin 2009). A single photon ionization (SPI) process is implemented allowing near 100% ionization efficiency for elements and compounds with ionization energies less than 10.5 eV. The FTICR-MS and LIBS isotope capability coupled with LOCI s wide mass range, mapping capability, high resolution, and automated data collection as well as data interpretation offers an alternative to the labor-intensive bulk analysis of traditional methods. 

Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS) FTICR-MS is based... 

Fourier transform mass spectrometry (FTMS) offers the highest mass resolution and mass measurement accuracy of all mass analyzers. FTMS, also referred to as Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS), can be adapted to a wide variety of ion sources and ion dissociation methods.The fundamental behavior of ions in FTMS instmments is based on the principle of ion cyclotron resonance (ICR), conceived and developed by E. O. Lawrence in the 1930s to build ion accelerators for nuclear physics experiments. ICR was first implemented in mass spectrometry in an instrument called the omegatron, developed by scientists at the National Bureau of Standards in the 1950s. Advances such as the application of Fourier transform methods to ICR spectrometry and the trapped analyzer cell resulted in the development of a powerful analytical instmment. 

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