Proteins/peptides, drug delivery

Kochendoerfer G. (2003). Protein Peptide Drug Delivery - Third International Conference. Minimally invasive delivery methods 22-23 September 2003, Philadelphia, PA, USA. I Drugs 6,1043-1045. 

Li JK, Wang N, Wu XS (1998) Poly(vinyl alcohol) nanoparticles prepared by freezing-thawing process for protein/peptide drug delivery. J Control Release 56 117-126... 

During the past 10 years, one of the most exciting developments in the oral peptide drug delivery was the identification of PEPT1. This is a significant finding because this carrier protein is known to play a critical role in the absorption of... 

Sood, A., and R. Panchagnula. 2001. Peroral route An opportunity for protein and peptide drug delivery. Chem Rev 101 3275. 

Luangtana-anan M, Opanasopit P, Ngawhirunpat T, Nunthanid J, Sriamornsak P, Limmat-vapirat S, Lim LY (2005) Effect of chitosan salts and molecular weight on a nanoparticulate carrier for therapeutic protein. Pharm Dev Technol 10(2) 189-196 Mackay M, Phillips J, Hastewell J (1997) Peptide drug delivery Colonic and rectal absorption. Adv Drug Del Rev 28(2) 253-273... 

Smith, P.L., Wall, D.A., Gochoco, C.H. and Wilson, G. (1992) Routes of Delivery Case Studies Oral absorption of peptides and proteins. Advanced Drug Delivery Reviews, 8 253-290. 

Li, J. K., Wang, N., and Wu, X. S. (1997), A novel biodegradable system based on gelatin nanoparticles and poly (lactic-co-glycolic acid) microspheres for protein and peptide drug delivery, J. Pharm. Sci., 86(8), 891-895. 

Gombotz, W.R. Pettit, D.K. Biodegradable polymers for proteins and peptide drug delivery. Bioconjugate Chem. 1995, 6, 332-351. 

Dantzig, A.H. (1998) Oral absorption of beta-lactams by intestinal peptide transport proteins. Advanced Drug Delivery Reviews, 23, 63-76. 

POLY CATIONIC PEPTIDES AND PROTEINS IN DRUG DELIVERY FOCUS ON NONCLASSICAL TRANSPORT... 

Peptide and protein nasal drug delivery have challenges related to their unique physical and chemical properties and comprise issues of chemical stability, loss due to physical absorption (especially for low-dose/high-potency molecules) and self-aggregation. The two key factors for nasal delivery of peptides are molecular mass and lipophilicity. The transitional area between a predicted good absorption and a predicted increasing difficulty of absorption is a molecular mass of about 1,000 (McMartin et al. 1987). Complete absorption of a peptide, by... 

Reddy I. Protein and peptide drug delivery. In Zito SW, ed. Pharmaceutical Biotechnology A Programmed Text. Lancaster, PA Technomic Publishing, 1997 159-182. 

Blood-brain barrier (BBB), one barrier separating the central nervous system (CNS) from the periphery, located at the endothelial cells of the brain tissue capillaries besides the blood-cerebrospinal fluid barrier (B-CSF-B) at the choroid plexus and the circumventricular organs. Peptides and protein drugs are generally excluded from transport from blood to brain. However, a chimeric peptide strategy for peptide drug delivery allows the delivery of... 

---