Proteinases, arthritis

Zhang, Z., Winyard, P.G., Chidwick, K., Farrell, A., Pemberton, P., Carrell, KW. and Blake, D.R. (1990). Increased proteolytic cleavage of ai-antitrypsin (ai-proteinase inhibitor) in knee-joint synovial fluid from patients with rheumatoid arthritis. Biochim. Soc. Trans. 18, 898-899. 

Bigg HE, Rowan AD. The inhibition of metallo-proteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis. Curr Opin Pharmacol 2001 1 314-20. 

Although ribozymes have been shown to work in vitro in cellular assays, there are few reports demonstrating their efficacy in vivo. One such success utilized the rabbit model of IL-l-induced arthritis. In this model, IL-1 is believed to generate the formation of a proteinase mediator called stromelysin, which participates in the inflammatory condition. The intra-articular administration of ribozymes directed against stromelysin mRNA has been reported to produce a reduction in the message for this mediator in synovial fluid. 

ANCA-4. Slot MC,Tervaert JW, Boomsma MM, Stegman CA Positive classic antineutrophil cytoplasmic antibody (C-ANCA) titer at stitch to azathioprine therapy assoiated with repapse I proteinase 3-related vasculitis. Arthritis Rheum 51 269-273. 

Neutral Proteinases in Rheumatoid Arthritis Arnold L. Gronsky, Christine Winslow Buermann 14, 219 ... 

In rheumatoid arthritis, collagenous tissues of the joint (including articular cartilage) are eroded by collagenases and neutral proteinases derived from proliferating cells of the synovial membrane and leukocytes. Therapeutic approaches may depend on regulation of collagen synthesis, breakdown, or both. 

B8. Banks, R. E., Evans, S. W Taylor, K. F., Bird, H. A., and Whicher, J. T. Measurement of plasma concentrations of polymorphonuclear elastase- alpha 1 proteinase inhibitor (elastase-alpha 1 antitrypsin) in patients with rheumatoid arthritis Interference by rheumatoid factor. Ann. Rheum. Dis. 49, 18-21 (1990). 

Connective tissue destruction during inflammatory diseases, such as chronic wound, chronic leg ulcers, or rheumatoid arthritis, is the result of continuous supply of inflammatory cells and exacerbated production of inflammatory cytokines and matrix proteinases (Senni et al., 2006). According to the Senni et al. (2006), fucoidan from Ascophyllum nodosum is a potent modulator of connective tissue proteolysis. Further, the authors suggested that fucoidan could be used for treating some inflammatory pathology in which uncontrolled extracellular matrix degradation takes place. 

Maksymowych WP, Nation N, Nash P et aL Amelioration of antigen induced arthritis in rabbits treated with a secreted viral serine proteinase inhibitor. J Rheumatol 1996 23 878-882. 

Brahn , Do L, Lee S et al. Suppression of collagen-induced arthritis with a serin proteinase inhibitor cloned from a myxoma viral sequence. Arthritis and rheumatism 2000 annual scientific meeting, Philadelphia, PA. Abstract Supplement, American College of Rheumatology 2000 abstract no. 1000 43(9). 

Hydroxamic acids, which have been extensively studied as metalloenzyme inhibitors and have been shown to be potent inhibitors of matrix metallo-proteinases, are a family of zinc-dependent enzymes associated with diseases such as cancer, arthritis and multiple sclerosis. 

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