Protein historical perspective

As noted above, whole-cell MALDI-TOF MS was intended for rapid taxonomic identification of bacteria. Neither the analysis of specific targeted bacterial proteins, nor the discovery of new proteins, was envisioned as a routine application for which whole cells would be used. An unknown or target protein might not have the abundance or proton affinity to facilitate its detection from such a complex mixture containing literally thousands of other proteins. Thus, for many applications, the analysis of proteins from chromatographically separated fractions remains a more productive approach. From a historical perspective, whole-cell MALDI is a logical extension of MALDI analysis of isolated cellular proteins. After all, purified proteins can be obtained from bacteria after different levels of purification. Differences in method often reflect how much purification is done prior to analysis. With whole-cell MALDI the answer is literally none. Some methods attempt to combine the benefits of the rapid whole cell approach with a minimal level of sample preparation, often based on the analysis of crude fractions rather... 

The term reverse phase protein microarray was first coined in 2001 by Paweletz et al. (5) in the landmark paper which introduced the platform and demonstrated its utility for analyzing proteins derived from laser capture microdissected (LCM) prostate cancer. RPMAs have also been referred to by other names in the literature including lysate arrays, reverse phase lysate arrays, protein microarrays, and reverse phase protein arrays (6). A very nice historical perspective on the development of RPJMA technology is presented in a review by Mueller et al. (6). A detailed description of the methods for performing RPMA is beyond the scope of this chapter and would be redundant because there are... 

R. A., Horn, D.M., Fridriksson, E.K., Kelleher, N.L., Kruger, N.A., Lewis, M.A., Carpenter, B.K., McLafferty, F.W. Electron capture dissociation for structural characterization of multiply charged protein cations. Anal. Chem. 2000, 72, 563-73. [d] Zubarev, R.A., Haselmann, K.F., Budnik, B., Kjeldsen, F., Jensen, F. Account towards an understanding of the mechanism of electron-capture dissociation a historical perspective and modern ideas. Eur. J. Mass Spectrom. 2002, 8, 337-49. 

R A. Burnham, The Rendering Industry A Historical Perspective, in D. A. Franco and W. Swanson, eds.. The Original Recyclers, The Animal Protein Producers Industry, The Fats and Proteins Research Foundation and The National Renderers Association, Alexandria, Virginia, 1996. 

Woodcock J, Griffin J, Behrman R, et al. The FDA s assessment of follow-on protein products a historical perspective. Nat Rev Drag Disco 2007 6(6) 437-442. 

Let us then accept that any biosphere will have much the same molecular substrate. The objection could still be raised that this base level of biomolecular commonality has little bearing on the diversification of life. To return to hemerythrin, this protein occurs in animals as diverse as annelids, brachiopods, priapulids, and sipunculans but (so far as we know) it has little, if any, bearing on the diversification of these three sorts of worm and a bivalved animal. Rather, one needs now to sliift perspective to ask to what extent the nexus of evolution is controlled or governed by predeterminants, possible pathways, and incumbencies. Do these undermine, if not negate, any possibility of evolutionary inevitabilities Recall that, from a historical perspective, evolution is faced with repeated decisions based... 

Johnson, L.A. D.J. Myers D.J. Burden. Historical perspectives on production and utilization of soy proteins, i. early oriental uses and industrial uses. INFORM (AOCS) 1992a, 3. 282-290. 

Constantino HR, Liauw S, Mitragotri S, et al.. The pharamaceutical development of insulin historical perspectives and future directions. In Shahrokh Z, Sluzky V, Cleland JL, et al., Eds. Therapeutic protein and peptide formulation and delivery. American Chemical Society Symposium Series, Washington DC, American Chemical Society 1997 675 29-66. 

In Abramowicz DA (ed). Biocatalysis. Van Nostrand Reinhold, New York, pp 277-318 Nasser W, Chalet F, Robert-Baudouy J (1990) Purification and characterization of extracellular pectate lyase from Bacillus subtilis. Biochimie 72(9) 689-695 Neidleman SL (1991) Historical perspective on the industrial uses of biocattilysts. In Dordick JS (ed). Biocatalysts for industry. Plenum Press, New York, pp 21-33 Neuhaus W, Novalin S, Klimacek, M et al. (2006) Optimization of an innovative hoUow-fiber process to produce lactose-reduced skim milk. Appl Biochem Biotechnol 134(1) 1-14 Nield BS, Willows RD, Torda AE et al. (2002) New enzymes from environmental cassette arrays functional attributes of a phosphotransferase and an RNA-methyltransferase. Protein Sci 13 1651-1659... 

Krebs EG (1983) Historical perspectives on protein phosphraylation and a classification system for protein kinases. Philos Trans R Soc Lond B Biol Sci 302 3-11... 

Berman HM (2008) The Protein Data Bank a historical perspective. Acta Cryst A64 88-95 Berman HM, Olson WK, Beveridge DL et al (1992) The Nucleic-Acid Database. Biophys J 63 751-759... 

The second section. Perspective Macro- and Microinteractions of Water and Polymers, consists of three chapters. It covers a brief historical introduction leading to an insight into selected aspects of current thought on interactions of water with model solutes and proteins [4], consideration of water-polymer and ice-polymer interfacial regions [5], and examination of stages in the process of protein hydration assessed by a variety of types of measurements [6]. 

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