Long-circulating nanoparticles

Moghimi, S. M., and Szebeni, J. (2003), Stealth liposomes and long circulating nanoparticles Critical issues in pharmacokinetics, opsonization and protein-binding properties, Prog. Lipid Res., 42(6), 463-478. 

Passirani C, Barratt G, Devissaguet J P, et al. (1998). Long-circulating nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate). Pharm. Res. 15 1046-1050. 

Nakada, Y., Tudomi, R., Sakurai, K., Takahashi, Y., 1998, Evaluation of long-circulating nanoparticles using biodegradable ABA triblock copolymers containing of poly(L-lactic acid) A-blocks attached to central poly(oxyethylene) B-blocks in vivo. Int. J. Pharm. 175 109-117. 

B. Romberg, W. Hennink, and G. Storm, Sheddable coatings for long-circulating nanoparticles. Pharmaceutical Research, 25 (1) 55-71, 2008. 

Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles theory to practice. Pharmacol Rev 2001 53 283. 

Chen D.B. et al.. In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel, Chem. Pharm. Bull., 49, 1444, 2001. 

Calvo, P., et al. 2001. Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug... 

Allcock and coworkers developed derivatives of the phosphazene polymers suitable for biomedical applications [35, 36]. Long-circulating in the blood, 100-120 nm in diameter, PEO-coated nanoparticles of the poly(organophospazenes) containing amino acids have been prepared. The PEO-polyphosphazene copolymer or poloxamine 908 (a tetrafunctional PEO copolymer) has been deposited on their surface [37]. 

Kaul, G., and Amiji, M. (2002), Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery, Pharm. Res., 19(7), 1061-1067. 

Additional advantages can be obtained by changing nanoparticle surface properties, for example, good stability, mucoadhesion, and long circulation time. For example, the in vivo long-circulating effect is achieved either by coating... 

New functions can be obtained by modifications of SLNs. Incorporation of Tween 80 and Poloxamer 188 can stabilize SLNs to achieve long-circulating or crossing blood-brain barrier effects [112], Recently, novel nanoparticles called polymer-lipid hybrid nanoparticles (PLNs) were developed [113]. They can entrap cationic anticancer agents (e.g., doxorubicin) effectively by incorporation of an anionic lipophilic polymer into lipids to treat multidrug-resistant (MDR) cancers. 

R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat. Mater. 2006 5 118-122. 

Calvo P, Gouridn B, Chacun H, Desmaele D, D Angelo J, Noel J, Georgin D, Fattal E, Andreux J, Couvreur P (2001) Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug canier for brain delivery. Pharm Res 18 1157—1166. 

Vittaz, M. Bazile, D. Spenlehauer, G. Verrecchia, T. Veillard, M. Puisieux, F. Couvreur, P. Effect of PEO surface density on long circulating PLA-PEO nanoparticles which are very low complement activators. Biomaterials 1996,17, 1575-1581. 

Kirpotin DB et al (2006) Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 66 6732-6740... 

M.C. Ilium, L. Long circulating biodegradable 68. poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer. Biomaterials 1997, 18, 1147-1152. 69. 

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