Prostaglandin release inhibition

Cytotoxics cause an elevation of dopamine levels in the area postrema in animal studies and may release prostaglandins and inhibit enzymes such as enkepha-linases to allow increased levels of enkephalins to activate opioid receptors on dopaminergic nerves. 

Naproxen, a non-steroidal anti-inflammatory drug, inhibits prostaglandin release through inhibition of the cyclo-oxygenase-2 enzyme, producing an analgesic and anti-inflammatory effect. 

Blood Prostaglandin Ej inhibits platelet aggregation, whereas thromboxane A2 induces platelet aggregation. Prostaglandins A2, E1( and E2 enhance erythropoiesis by augmenting the renal cortical release of erythropoietin. 

Furosemide inhibits the absorption of indometacin (42), while the diuretic and hypotensive effects of most diuretics are blunted by indometacin and probably also other NSAIDs (43). Intravenous furosemide is commonly given to patients with acute heart failure to relieve pulmonary congestion. Symptomatic relief occurs before the onset of diuresis, and the beneficial effect is believed to result from a venodUator action of furosemide, which precedes its diuretic effect. This venodilator response is inhibited by indometacin, suggesting that it occurs through local prostaglandin release. 

Bradykinin releases prostaglandins from phospholipids in a variety of systems, an effect thought to augment the activities of this peptide. That bradykinin activates phospholipase A2, either directly or indirectly , is suggested by the inhibition of bradykinin-induced prostaglandin release by the... 

Nedocromil sodium is a mast-cell stabilizer that inhibits release of mediators from inflammatory cell types associated with asthma, including histamine from mast cells and beta-glucuronidase from macrophages. It may also suppress local production of leukotrienes and prostaglandins and inhibit development of bronchoconstriction responses to inhaled antigen and other challenges such as cold air. It is... 

Levasseur, S., Kostelec, M. and Burke, G. (1984). RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes. Prostaglandins, 27, 675—651... 

Kambayashi T, Alexander HR, Fong M, Slrassmann G. Potential involvement of IL-10 in suppressing tumor-associated macrophages. Colon-26-derived prostaglandin E2 inhibits TNF-alpha release via a mechanism involving IL-10. J Immunol 1995 154 3383. 

Gryglewski KJ, Panczenko B, Korbut R, Grodzinska L, Ocetkiewicz A Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. PA.06tagZancUyi6 10 343, 1975. 

Nonimmunologic contact urticaria (NICU) occurs in individuals not sensitized to the contactant, i.e., almost any normal subject. The mechanism of action is the result of a direct release of vasoactive substances, which causes a localized response [20]. Prostaglandins are mediators in the reaction to at least benzoic and sorbic acids and to methyl nicotinate, and systemic or topical inhibitors of prostaglandin synthesis inhibit the reaction to these substances [21-23]. Ultraviolet radiation (UVB and UVA) has also been shown to inhibit NICU reactions to some substances [24]. The NICU reaction is often redness without edema rather than a real wheal-and-flare reaction. The appearance of clinical signs depends mainly on the duration of exposure, the concentration of the contactant and other factors, such as rubbing or scratching. The reaction usually remains localized and systemic reactions are probably... 

Medical pain HI antihistamines appear to be effective in treating renal coUc pain, one of the most severe forms of pain. The mechanism involves the inhibition of renal vasodilatation in the occluded ureter, the inhibition of prostaglandin release, and prevention of spontaneous urethral contractions. H2 receptor antagonists are used for the treatment and maintenance of gastroesophageal reflux disease, peptic ulcer disease, and dyspepsia. 

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