Prostaglandin F„ , PGF

PGF, PGH Prostaglandins F and H PGI2 Prostaglandin I2 also known as prostacyclin... 

There are two main types of prostaglandins that differ in the oxygen function at C9, which is a carbonyl in Series E (PGE) and hydroxyl in Series F (PGF). Examples follow ... 

Figure 2.1 Excretion of urinary prostaglandins E (PGE)- and F (PGF)-like substances, kallikrein (KK), urine volume (UV), and sodium excretion (U, j3V) in rats injected with deoxycorticosterone (DOC), 5 mg day for 14 days. From day 11, aprotinin, 50 000 kiu was injected subcutaneously twice daily for 4 days. Values are means indicates significant differences p < 0.05) compared with control values...

Lacroix Pepin, N., P. Chapdelaine et al. 2013. Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases AKRlAls complement AKRlBls as potent PGF synthases. Pjjjj J lMidins Otherl idMe 106 124—132. 

Recently, a novel class of prostaglandin derivatives, PG-1,15-lactones (Fig. 1) of both E [16] and F [17] series, has been reported to occur in the opisthobranch mollusc Tethys fimbria, along with smaller amounts of some of the corresponding PGs. Some lactones were present mainly in the mucous secretion and dorsal appendages known as cerata, while others were more abundant in the mantle. Fatty acid esters of PGF-1,15-lactones (C9 and Cu) were found only in T. fimbria eggmasses and reproductive glands (ovotestis). The structural variety of the lactones and the data on their distribution in the body... 

The nomenclature for the prostaglandins (PGs) involves the assignment of a capital letter (PGE), an Arabic numeral subscript (PGEi), and, for the PGF family, a Greek letter subscript (e.g., PGF2C,). The capital letter, in this case F, refers to the ring substituents shown in figure 35.5. 

Fig. 2. Effect of oxytocin (0,1,10 or 100. 1.000 or 10.000 ng/mL medium) on prostaglandin (PG)F release by cultured porcine ovarian granulosa cells. Values are means SEM. Sig-nificant differences (P< 0.05) between cells cultured with and without exogenous oxytocin. Methods of isolation and culture of ovarian granulosa cells, as well as the PGF radioimmunoassay are described in (10).

First, different PGs may have opposite effects on the same organ prostaglandins of the E type are bronchodilators whereas the F compounds are bronchoconstric-tors the cervix of the uterus is relaxed by PGEs but contracted by PGFs. 

Interestingly, although fish reproductive lifestyles are highly diverse, the steroids and F prostaglandins (PGFs) from which hormonal pheromones are derived appear highly conserved. For example, in all fish examined, estradiol-17p (E2) induces vitellogenesis... 

Watanabe, K. 2011. Recent reports about enzymes related to the synthesis of prostaglandin (PG) F(2) (PGF(2alpha) and 9alpha, 11 beta-PGF( 2B. J Riochem 150(61 593-596. 

Cottee F, Flower RJ, Moncada S, Salmon JA, Vane JR Synthesis of 6-keto-PGF by ram seminal vesicle microsomes. Prostaglandins (14) 413-423, 1977. 

The crude prostaglandin extract was purified and fractionated by TLC on silicagel F, using the organic phase of ethyl acetate - 2,2,4-trimethyl pentane-acetic acid - water (11 0 50 20 100) in a non-equilibrated tank and applying the double development technique as described by Sun et al.(7) Under the conditions used, 6-oxo PGF elutes as a sharp zone and is well resolved from coloured haem zone, which was always... 

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