Propyl alcohol toxicity

On the basis of acute animal studies, n-propyl alcohol appears to be slightly more toxic than isopropyl alcohol. No chronic effects have been reported in humans, although a human fatality has been ascribed to ingestion. Exposure to 400 ppm for 3-5 minutes will reportedly... 

Note Polar solvent soluble in water, alcohols, ethers, many hydrocarbons, and oils flammable and moderately toxic by ingestion, inhalation, and skin absorption incompatible with strong oxidizers. Synonyms dimethyl carbinol, sec-propyl alcohol, 2-propanol, isopropyl alcohol. 

Toxicity Propyl alcohol is not known to cause toxicity to animals and humans unless it is used improperly. Propyl alcohol vapor in high concentrations causes mild irritation to eyes, conjunctiva, and mucous membranes of the upper respiratory tract, and CNS depression.111... 

Isopropyl alcohol is the alcohol in rubbing alcohol. It is used as an antiseptic, and in microbiology laboratories it is used to kill bacteria on benchtops and numerous materials. Isopropyl alcohol is toxic if taken internally. Notice that n-propyl alcohol and isopropyl are isomers. 

Reactive substances that contain functional groups likely to undergo adverse biochemical processes. An interesting comparison is that between two 3-carbon alcohols, propyl alcohol (CH3CH2CH2OH) and allyl alcohol (H2C=CHCH20H). Propyl alcohol is only about 1/100 as toxic as allyl alcohol. The toxicity of allyl alcohol is due to the reactive double bond between carbon atoms. 

The amines are a group of compounds with the general formula R-NHj, and all the common amines are hazardous. As a class the amines pose more than one hazard, being flammable, toxic, and, in some cases, corrosive. The amines are an analogous series of compounds and follow the naming pattern of the alkyl halides and the alcohols that is, the simplest amine is methyl amine, with the molecular formula of CH NHj. Methyl amine is a colorless gas with an ammonia-like odor and an ignition temperature of 806°F. It is a tissue irritant and toxic, and it is used as an intermediate in the manufacture of many chemicals. Ethyl amine is next in the series, followed by propyl amine, isopropyl amine, butyl amine and its isomers, and so on. 

We carried out a great deal of work on the relationship between the above physiological effects and chemical constitution, and it was shown conclusively that the more potent compounds were those derived from secondary alcohols.3 Thus, for example, di-isopropyl phosphorofluoridate is very much more potent than diethyl phosphorofluoridate or di-ra-propyl phosphorofluoridate and the toxicity of the dicycZohexyl ester is of a high order (L.C. 50 for mice, rats and rabbits was 0-11 mg./l.). Din-butyl phosphorofluoridate had low toxicity and produced only feeble... 

Among many esters, di w propyl and diisopropyl phosphoro-fluoridate were prepared by the action of phosphorus oxy-dichlorofluoride on ra-propyl and isopropyl alcohol respectively. The n-ester was less toxic and possessed only feeble myotic... 

It was obviously of interest to determine whether other esters of fluoroacetic acid would prove to be more or less toxic than the methyl ester. In the phosphorofluoridate series, for example, we found that esters of secondary alcohols were far more potent than those of primary alcohols for instance, di-isopropyl fluorophosphonate (I) was a compound of considerable activity. Accordingly ethyl, ra-propyl and isopropyl fluoroacetates were prepared by heating the corresponding esters of chloroacetic acid in the rotating autoclave with potassium fluoride. The toxicity figures of these esters were very similar to those of methyl fluoroacetate. 

Synonyms Hydrocinnamic acetate 3-Phenyl-1-propanol acetate Phenylpropyl acetate 3-Phenyl propyl acetate Empirical C11H14O2 Formula C6H5CH2CH2CH2OOCCH3 Properties Colorless liq., spicy floral odor sol. in alcohol insol. in water m.w. 178.25 dens. 1.012 flash pt. > 212 F ref. index 1.494 Toxicology LD50 (oral, rat) 4700 mg/kg mildly toxic by ing. TSCA listed Precaution Combustible liq. 

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