13-propanediol, 2-Amino-2-

Hexahydro-3-(hydroxymethyl)-8a-methyl-2-phenyl[2S,3S.8aR]-5-oxo-5H-oxazolo[3.2-a]pyridine 5H-Oxazolo[3,2-a]pyridin-5-one, hexahydro-3-(hydroxymethyl)-8a-methyl-2-phenyl-, [2S-(2a,3p,8ap)]- (12) (116950-01-7) (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol 1,3-Propanediol, 2-amino-1 -phenyl (9) (3306-06-7)... 

Amino-1-phenyl-1,3-propanediol, (1S,2S)-(+)- 1,3-Propanediol. 2-amino-1 -phenyl ... 

AEPD AEPD 85 AI3-03358 Aminoethyl propanediol 2-Amino-2-ethylpropanediol 2-Amino-2-ethyl-1,3-propanediol EINECS 204-101-2 2-Ethyl-2-amino-propanediol NSC 8803 1,3-Propanediol, 2-amino-2-ethyl- AEPD -85 AEPD . Pigment dispersant, neutralizing amine, corrosion inhibitor, acid-salt catalyst, pH buffer, chemical and pharmxeutical intermediate and solubilizer. Chemical intermediate, formaldehyde scavenger, acid-salt catalyst for permanent-press resins, corrosion Inhibitor. Crystals mp = 37,5° bpto = 152-153° d = 1.0990 freely soluble In H2O soluble In alcohols pH 0.1,1M aqueous solution, Whittaker Clark Daniels. 

Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride 2-Amino-2-hydroxymethyl-1,3-propane-diol hydrochloride EINECS 214-684-5 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride Tris hydro-chloride Tris hydrochloride buffer. A buffer used exten-sively in biochemical research. Crystals mp = 150-152 (dec). Am. Biorganics Janssen Chimica Sigma-Aldrich Fine Cham. U.S. BioChem. 

Amino-2-(hydroxymethyl)-l, 3-propanediol 1, 3-Propanediol, 2-amino-2-(hydroxymethyl)- ... 

The most important members of this group from a commercial standpoint are monoethonolamine, diethanolamine, and triethanolamine. Also ovailoble in commercial quantities are the aminohydroxy derivatives of nltroparoffins, which are 2-amino-1-butanol, 2-amlno-2-methyl-1-propanol, 2-amlno-2-methyl-1,3-propanediol, 2-amino-2-ethyl-l,3-propanedial, and trls(hydroxymethyl)aminomethane. 

A problem in the use of many amines as pH buffers is that they are liquids or gases at room temperature and are difficult to obtain pure. Of the solid amines, 4-amino-pyridine, imidazole and Tris are ordinarily available in acceptable purity, but others, such as 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-l-propanol and hexa-methylenediamine, may need further purification, commonly by distillation. However it is difficult to remove residual monoethanolamine and diethanolamine from triethanolamine. A general method for the purification of amines is through the preparation of their hydrochlorides. 

Synonyms AEPD Aminoamylene glycol 2-Amino-2-ethyl-1,3-propanediol 2-Ethyl-2-aminopropan-1,3-diol 2-Ethyl-2-aminopropanediol 2-Ethyl-2-amino-1,3-propanediol 1,3-Propanediol, 2-amino-2-ethyl Classification Aliphatic diol amino glycol Empirical CsH-.NOj Formula CH20HC(C2H5)NH2CH20H... 

Aminoamylene glycol. See Aminoethyl propanediol Amino bispropyl dimethicone... 

The nitro alcohols in Table 1 are manufactured in commercial quantities however, three of the five of them are used only for the production of the corresponding amino alcohols. 2-Methyl-2-nitro-l-propanol (NMP) is available as the crystalline soHd or as a mixture with siHcon dioxide. 2-Hydroxymethyl-2-nitro-1,3-propanediol is available as the soHd ( 9.15/kg), a 50% solution in water ( 2.33/kg), a 25% solution in water ( 1.41/kg), or as... 

Polymers. AH nitro alcohols are sources of formaldehyde for cross-linking in polymers of urea, melamine, phenols, resorcinol, etc (see Amino RESINS AND PLASTICS). Nitrodiols and 2-hydroxymethyl-2-nitro-l,3-propanediol can be used as polyols to form polyester or polyurethane products (see Polyesters Urethane polymers). 2-Methyl-2-nitro-l-propanol is used in tires to promote the adhesion of mbber to tire cord (qv). Nitro alcohols are used as hardening agents in photographic processes, and 2-hydroxymethyl-2-nitro-l,3-propanediol is a cross-linking agent for starch adhesives, polyamides, urea resins, or wool, and in tanning operations (17—25). Wrinkle-resistant fabric with reduced free formaldehyde content is obtained by treatment with... 

Nitromethane. The nitroparaffins are used widely as raw materials for synthesis. Nitromethane is used to produce the nitro alcohol (qv) 2-(hydroxymethyl)-2-nitro-l,3-propanediol, which is a registered biocide useful for control of bacteria in a number of industrial processes. This nitro alcohol also serves as the raw material for the production of the alkanolamine (qv) 2-amino-2-(hydroxymethyl)-l,3-propanediol, which is an important buffering agent useful in a number of pharmaceutical appHcations. 

Nltropropane. The alkanolamines (qv), 2-amino-2-ethyl-l,3-propanediol and 2-amino-l-butanol, are produced by the two-step process described previously. 

In the piepaiation of ioveisol (12) (41), the key intermediate (23) is prepared from the diacid (20) by the action of thionyl chloride followed by 3-amino-l,2-propanediol. The alcohol groups of (23) are protected as the acetates (25), which is then N-acylated with acetoxyacetyl chloride and deprotected in aqueous methanol with sodium hydroxide to yield (26). N-alkylation of (26) produces ioversol (12). 

The steric bulk of the three iodine atoms in the 2,4,6-triiodoben2ene system and the amide nature of the 1,3,5-substituents yield rotational isomers of the 5-A/-acyl-substituted 2,4,6-triiodoisophthalamides. Rotational motion in the bonds connecting the side chains and the aromatic ring is restricted. These compounds also exhibit stereoisomerism when chiral carbon atoms are present on side chains. (R,5)-3-Amino-l,2-propanediol is incorporated in the synthesis of iohexol (11) and ioversol (12) and an (3)-2-hydroxypropanoyl group is used in the synthesis of iopamidol (10). Consequendy, the resulting products contain a mixture of stereoisomers, ie, meso-isomers, or an optical isomer. 

Amino-2-methyl-l,3-propanediol [115-69-5] M 105.1, m 111 , b 151-152 /10mm, pK 8.80. Crystd three times from MeOH, dried in a stream of dry N2 at room temp, then in a vacuum oven at 55 . Stored over CaCl2 [Hetzer and Bates J Phys Chem 66 308 1962],... 

Elution 0.05 M GTA buffer, pH 7.0 (G, 3,3-dimethylglutaric acid T, trishydroxyaminomethane A, 2-amino-2-methyl-l,3-propanediol) plus indicated salt. 

The AMAPs (2-[ arylmethyl amino]-l,3-propanediols) are a class of planar polycyclic aromatic derivatives, which contain polar side-chains. They are known to be DNA intercalators and possess broad spectrum antitumour activity. An approach to C-radiolabelled AMAP derivative 40 used the Bucherer reaction as an initial starting reaction. 2-Naphthol was reacted with 4-bromophenylhydrazine 38 in the presence of sodium metabisulfite and HCl to afford 39. Subsequent derivatisation of 39 afforded 40. 

The first synthesis and use of a chiral oxazoline was reported by Meyers in 1974. The chiral oxazoline 1 was prepared in two steps by condensation of (-i-)-l-phenyl-2-amino-1,3-propanediol (6) with the ethyl imidate of propionitrile followed by 0-methylation of the resulting alcohol 7 with NaH/Mel. Meyers demonstrated chiral oxazoline 1 could be... 

Amino-2,4,6-triiodo-isophthalic acid Thionyl chloride DL-2-Acetoxypropionyl chloride 2-Amino-1,3-propanediol... 

A mixture of 50 parts by weight of racemic 2-acetylamino-1 -(4-methylmercaptophenyl)-1,3-propanediol, 100 parts by weight of concentrated hydrochloric acid, and 500 parts by weight of water was warmed on a steam bath for thirty minutes. The resulting solution was cooled to about 40 C and was then made strongly alkaline by addition of 35% aqueous sodium hydroxide solution. The alkaline solution was then refrigerated. The white solid which separated from the cooled solution was collected on a filter. There was thus obtained 27 parts by weight of 2-amino-1-(4-methylmercaptophenyl)-1,3-propanediol. This product melted at 130.7°C to 131 after recrystallization from methanol. 

A mixture of 1.1 g of 2-amino-1-(4-methylmercaptophenyl)-1,3-propanediol, obtained as described above and 1.6 ml of ethyl dichloroacetate was heated on a steam bath for three hours. The resulting viscous yellow oil was dissolved in 25 ml of ethylene chloride and filtered hot with charcoal, and the filtrate was allowed to cool to about 25°C. From the filtrate there separated 0,92 g of tiny white leaflets which were collected on a filter. Recrystallization of this product, which was a dextro-rotary form of 2-dichloroacetylamino-1-(4-methylmercapto-phenyl)-1,3-propanediol from nitroethane yielded the pure product, which melted at 111.6°C to 112.6°C,... 

Chemical Name 2-Amino-2-hydroxymethyl-1,3-propanediol Common Name Trometamol Structural Formula ... 

Amino-1,3-propanediol lopamidol 2-Aminopyrazine Sulfalene 2-Aminopyridine Diphenpyramide Methapyrilene HCI Phenyramidol Pyrilamine Sulfadiazine Tripelennamine Zolimidine... 

Among the amines that have been resolved with (-)-DAG are a-phenylethylamine (a-methylbenzenemethanamine),s [R-(R, R )]-2-amino-l-(4-nitrophenyl)-l, 3-propanediol,61,2,3,4,5,6,7,8-octahydro-l-(4-methoxyphenylmethyl)isoquinoline, 3-methoxymorphinan, 1,2,3,4-tetrahydro-7-methoxy-4-phenylisoquinoline, 3-hydroxy-A7-methyl-... 

Alcohol oxidoreductases capable of oxidizing short chain polyols are useful biocatalysts in industrial production of chiral hydroxy esters, hydroxy adds, amino adds, and alcohols [83]. In a metagenomic study without enrichment, a total of 24 positive clones were obtained and tested for their substrate specifidty. To improve the detedion frequency, enrichment was performed using glycerol or 1,2-propanediol and further 24 positive clones were deteded in this study. 

CN 2-[2-(2-amino-9//-purin-9-yl)ethyl]-1,3-propanediol diacetate (ester)... 

The blend is partially crosslinked with a vinyl monomer when dissolved in an organic aprotic solvent and has a pH of 5.0 or lower. The first block copolymer is prepared by polycondensing a bis-hydroxyalkyl ether, such as dipropylene glycol, diethylene glycol, and the like, with propylene oxide. Next, the resulting propoxylated diol is reacted with ethylene oxide to produce the block copolymer. The second copolymer is prepared by polycondensing 2-amino-2-hydroxymethyl-1,3-propanediol, commonly known as TRIS, with... 

In 2000, other S/N-ferrocenyloxazolines were prepared by Ai t-Haddou et al. starting from ehiral 2-amino-3-phenyl-l,3-propanediol. The corresponding P/N-analogues were also prepared in order to compare their efficiency in the test reaction. As shown in Scheme 1.68, both ligands gave good results in terms of both activity and enantioselectivity with a better result for the S/N ligand. 

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