1.2- Propanediol, diacetate

CN 2-[2-(2-amino-9//-purin-9-yl)ethyl]-1,3-propanediol diacetate (ester)... 

The 5 -(-)-2-cyclohexy 1-1,3-propanediol monoacetate (24) and the S-( )-2-phenyl-1,3-propanediol monoacetate (25) are key chiral intermediates for the chemoenzymatic synthesis of Monopril (26) (Fig. 10), a new antihypertensive drug which acts as an ACE inhibitor. The asymmetric hydrolysis of 2-cyclohexyl-1,3-propanediol diacetate (27) and 2-phenyl-1,3-propanediol diacetate (28) to the corresponding S-( - )-monoacetate (24) and S-( )-monoacetate (25) by porcine pancreatic lipase (PPL) and Chromobacterium viscosum lipase have been demon-... 

Figure 10 Preparation of chiral synthon for monopril asymmetric enzymatic hydrolysis of 2-cyclohexyl- and 2-phenyl-1,3-propanediol diacetate (27) and (28) to the corresponding S-(—)-monoacetates.

RN Patel, RS Robison, LJ Szarka. Stereoselective enzymic hydrolysis of 2-cyclo-hexyl- and 2-phenyl-1,3-propanediol diacetate in biphasic systems. Appl Microbiol Biotechnol 34 10-14, 1990. 

To sum up, the flavor constituents of plain and roasted cashew nuts are reported here for the first time. The mild flavor of cashew nuts can be attributed to the carbonyls, esters and lactones, especially to 5-heptene-2-one and 1,3-propanediol diacetate. Upon roasting, 2,6-dimethyl pyrazine, 2,6-diethyl pyrazine and the furanone are formed in larger amounts and from flavor profile also these compounds are likely to play a significant role in the characteristic aroma of roasted cashew nuts. 

Kaneko et al. reported the preparation of the key intermediate (-F)-12 of (—)-HA via the asymmetric Pd-catalyzed bicycloannulation of the p-keto ester 2 with 2-methylene-1,3-propanediol diacetate 11 (Scheme 4-8). The chiral ferrocenyl-phosphine ligand 13 gave 64% ee enantioselectivity. 

Pentaerythritoi Tetraacetate, 2,2 -Bts((acetyloxy)- ethyl]- 1,3-propanediol diacetate tetra-O-acety l pentaerythritoi pentaerythrityl tetraacetate Normosterol. 

Fig. 2.29. Preferred accommodation of 2- -alkenyl-1,3-propanediol diacetates in an active site model for PPL. Reproduced from J. Org. Chem., 57, 1540 (1992), by permission of the American Chemistry Society.

Pentaerythritol tetraacetate 2,2-Bis[(acetyloxy)methyl]-1,3-propanediol diacetate C13H20O9 697-71-7 304.293 tetr nd (w, bz) 83.6 1.2731 sH20 vsE10H, eth... 

Acylmethylene)propanediol diacetate 274 was prepared by Wadsworth-Em-mons olefination reaction of 1,3-diacetoxyacetone (272) with jS-keto phosphonate 273, and Pd-catalyzed reaction of 274 with methyl glycinate afforded the trisub-stituted pyrrole 275 [101]. 

Bis ((acetyloxy) methyl)-1,3-propanediol diacetate. See Pentaerythrityl tetraacetate... 

Pentaerythrityl tetraacetate CAS 597-71-7 EINECS/ELINCS 209-907-8 Synonyms Acetic acid, tetraester with 2,2-bis (hydroxymethyl)-l, 3-propanediol 2,2-Bis ((acetyloxy) methyl)-1,3-propanediol diacetate Normosterol Pentaer hritol tetraacetate 1,3-Propanediol, 2,2-bis (acetyloxy) methyl)-, diacetate... 

Dimethyl-4-allyl-4-hydroxymethyltetrahydrofuran (prepn. s. 205) added to a mixture of acetic anhydride and pyridine into which a steam of HCl has been passed, and refluxed 5 hrs. 2-allyl-2-methallyl-1,3-propanediol diacetate. Y 98.9%. B.K. Wasson et al., Gan. J. Chem. 39, 923 (1961). 

Allylbenzene added to ethereal butyllithium, allowed to stand overnight at room temp., added dropwise to an ice-cooled 2 M soln. of borane in tetrahydrofuran, stirred 5 hrs., treated in turn with water, 3 N NaOH, and HgOg, the resulting crude l-phenyl-l,3-propanediol allowed to react overnight with 1 1 acetic anhydride-pyridine 1-phenyl-1,3-propanediol diacetate. Y 65%. F. e. s. J. Klein and A. 

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