2-Amino-2-methyl-l,3-propanediol

Amino-2-methyl-l,3-propanediol [115-69-5] M 105.1, m 111 , b 151-152 /10mm, pK 8.80. Crystd three times from MeOH, dried in a stream of dry N2 at room temp, then in a vacuum oven at 55 . Stored over CaCl2 [Hetzer and Bates J Phys Chem 66 308 1962],... 

Elution 0.05 M GTA buffer, pH 7.0 (G, 3,3-dimethylglutaric acid T, trishydroxyaminomethane A, 2-amino-2-methyl-l,3-propanediol) plus indicated salt. 

Amino-2-methyl-l,3-propanediol Dinitrate under Aminomethylpropanediols in Vol l,p A232 -R... 

Amino-2-methyl- l, 3 propanediol 2-Amino-2-methyl-1,3-dibydroxy-propane or Bis(by-droxymethyl)metbyl-aminometbawe(called in Beil /3-Amino-/S-methyl-trimethylenglykol), HO-CHj-CfNHj )-CHa -OH... 

Note R.C.Elderfield et al [OSRD Rept 158 (1941), 7-8] prepd by condensing 2-amino-2-methyl-l,3-propanediol with 2,4-dinitro-chlorobenzene the product identified as 2,4-dinitrophenyl-bisfhydroxymethyl)-methylamine, mp 162—3°, which on nitration with mixed nitricsulfuric acid gave 2,4,6- trini trophenyl-( bi s- hydroxy )-tert-butylnitramine dinitrate, mp 159°,(See also under Anilinomethylpropanediol... 

Similar to basic drugs, development of pH-independent ER matrices for weakly acidic drugs is possible with incorporation of non-polymeric bases/salts of strong bases and polymeric pH modifiers [67-70]. The examples of basic excipients are sodium, potassium or magnesium salts of (bicarbonate, phosphate or hydroxide, magnesium oxide, 2-amino-2-methyl-l,3-propanediol (AMPD) and Eudragit ElOO. 

Page 24, 2-Amino-2-methyl-l,3-propanediol, following tine,read [1, 37, before 2-Amino-2-methyl-l-propanol). Mol. 

Similar solubility behavior of polyhydroxy compounds was shown in fused acetates by Burton and Crowell. Burton observed that solubility of several organic compounds at 200°C, in (Li, Na, K) acetate eutectic (mp 180°C) increases with the number of hydroxyl groups and with acidity. In weight percent the following approximate solubilities were determined methanol, 0.05% 2,4-dinitroaniline and 4-nitroaniline, < 0.5% hydroquinone and resorcinol, 1% 2-amino-2-hydroxymethyl-l, 3-propanediol and 2-amino-2-methyl-l,3-propanediol, I0% trimethylolethane and pentaerythritol were miscible in all proportions above their melting points. 

Phosphonomethylation of 2-amino-2-methyl-l,3-propanediol gave the dimethylene diphosphonic acid of 5-amino-5-methyl-l,3-dioxane. 

One of the earhest extensions of the list of possible buffers for biological work was Gomori s (1946) proposal of 2,4,6-trimethylpyridine, tris(hydroxymethyl)aminomethane and 2-amino-2-methyl-l, 3-propanediol. The use of peptides such as glycylglycine and, more particularly, N-dimethyl-leucylglycine (Leonis, 1948) as biological buffers is now of little more than historical interest because a much wider range of suitable, readily water-soluble buffer substances having soluble calcium salts has been developed. 

---