2-Amino-2-ethyl-l,3-propanediol

Nltropropane. The alkanolamines (qv), 2-amino-2-ethyl-l,3-propanediol and 2-amino-l-butanol, are produced by the two-step process described previously. 

Amino-2-ethyl-l,3-propanediol commercial alkanolamine, 2 114t physical properties of, 2 114t... 

The V-ethyl derivative of maleimide, at a concentration of 1 X 10 M, in 2-amino-2-(hydroxymethyl)-l,3-propanediol acetate buffer of pH 7.5, did not inhibit the enzyme. When measurements were made in the same buffer at pH 8.6 and at a V-ethylmaleimide concentration of 3 X 10 M, 25% inhibition occurred within 3.5 hours. The pH-dependency of the maleimide derivative reactions has been explained in terms of reaction mechanisms (the RS form reacting instead of RSH). " The effects of various buffers, that is, of salt composition, on the reaction, as well as the specificity of these reagents, remain to be investigated. 

The first synthesis and use of a chiral oxazoline was reported by Meyers in 1974. The chiral oxazoline 1 was prepared in two steps by condensation of (-i-)-l-phenyl-2-amino-1,3-propanediol (6) with the ethyl imidate of propionitrile followed by 0-methylation of the resulting alcohol 7 with NaH/Mel. Meyers demonstrated chiral oxazoline 1 could be... 

A mixture of 1.1 g of 2-amino-l-(4-methylmercaptophenyl)-l,3-propanediol, obtained as described above and 1.6 ml of ethyl dichloroacetate was heated on a steam bath for three hours. The resulting viscous yellow oil was dissolved in 25 ml of ethylene chloride and filtered hot with charcoal, and the filtrate was allowed to cool to about 25°C. From the filtrate there separated... 

CN 2-[2-(2-amino-9W-purin-9-yl)ethyl -l, 3-propanediol diacetate (ester)... 

Scheme 9.2 Formation of 2-amino-1-butanol in the hydrogenation of 2-ethyl-2-nitro-l,3-propanediol over Raney Ni.

Enantioenriched a>ChIoro Carboxylic Acids. Reaction of (lS,25)-l-pheny 1-2-amino-1,3-propanediol with the ethyl imidate of chloroacetonitrile gives (—)-2-chloromethyl-4-methoxymethyl-5-phenyl-2-oxazoline (eq 7). ... 

The most important members of this group from a commercial standpoint are monoethonolamine, diethanolamine, and triethanolamine. Also ovailoble in commercial quantities are the aminohydroxy derivatives of nltroparoffins, which are 2-amino-1-butanol, 2-amlno-2-methyl-1-propanol, 2-amlno-2-methyl-1,3-propanediol, 2-amino-2-ethyl-l,3-propanedial, and trls(hydroxymethyl)aminomethane. 

The following chiral reagents were employed for diastereomer formation before sample application and chromatography on silica gel or silica gel G TLC plates (L)-leucine Af-carboxyanhydride for D,L-dopa-carboxyl- " C separated with ethyl acetate/formic acid/water (60 5 35) mobile phase and detected by ninhydrin [7 f 0.38 (d)/0.56 (l)] [43] Af-trifluoroacetyl-L-prolyl chloride for D,L-amphetamine separated with chloroform/methanol (197 3) and detected by sulfuric acid/formaldehyde (10 1) (Rf 0.49 (d)/0.55 (l)) [44] Af-benzyloxycarbonyl-L-prolyl chloride for D,L-methamphetamine separated with n-hexane/ethyl acetate/acetonitrile/diisopropyl ether (2 2 2 1) and detected by sulfuric acid/formaldehyde (10 1) [/ f 0.57 (l)/0.61 (d)] [44] (l/ ,2/ )-(-)-l-(4-nitrophenyl)-2-amino-1,3-propanediol (levobase) and its enantiomer dextrobase for chiral carboxylic acids separated with chloroform/ethanol/acetic acid (9 1 0.5) and detected under UV (254 nm) light R[ values 0.63 and 0.53 for 5- and / -naproxen, respectively) [45] (5)-(4-)-a-methoxyphenylacetic acid for R,S-ethyl-4-(dimethylamino)-3-hydroxybutanoate (carnitine precursor) with diethyl ether mobile phase [/ f 0.55 R)/0J9 (5)] [46] and (5)-(4-)-benoxaprofen chloride with toluene/acetone (100 10, ammonia atmosphere) mobile phase and fluorescence visualization (Zeiss KM 3 densitometer 313 nm excitation, 365 nm emission) (respective R values of R- and 5-isomers of metoprolol, oxprenolol, and propranolol were 0.24/0.28, 0.32/0.38, and 0.32/0.39) [47]. 

Synonym 3-[Ethyl[3-methyl-4-[C5-nitro-2-thiazolyl)azo]phenyl]amino]-1,2-propanediol Source Draper, S. L. Montero, G. A. ... 

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