Promoter complex

The addition product, C QHgNa, called naphthalenesodium or sodium naphthalene complex, may be regarded as a resonance hybrid. The ether is more than just a solvent that promotes the reaction. StabiUty of the complex depends on the presence of the ether, and sodium can be Hberated by evaporating the ether or by dilution using an indifferent solvent, such as ethyl ether. A number of ether-type solvents are effective in complex preparation, such as methyl ethyl ether, ethylene glycol dimethyl ether, dioxane, and THF. Trimethyl amine also promotes complex formation. This reaction proceeds with all alkah metals. Other aromatic compounds, eg, diphenyl, anthracene, and phenanthrene, also form sodium complexes (16,20). 

Peters JM (2006) The anaphase promoting complex/ cyclosome a machine designed to destroy. Nat Rev Mol Cell Biol 7 644-656... 

Zachariae W, Nasmyth K 1999 Whose end is destruction cell division and the anaphase-promoting complex. Genes Dev 13 2039-2058... 

Daum, J.R. et al. (2000) The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome. Curr. Biol. 10(23), R850-R857. S1-S2... 

Also identified during the mid-1990s was the APC (anaphase promoting complex - also known as the cyclosome), another multi-subunit cullin-containing E3 that mediates ubiquitylation of mitotic cyclins [18, 19]. Mdm2, initially thought to be a HECT domain variant, was shown in 1997 to have E3 activity towards p53 in vitro [20]. For the non-HECT E3s no common structural feature had been detected. Thus, by 1997 the only defined molecular signature for E3 activity was the HECT domain. 

Page, A. M. and P. Hieter, The anaphase-promoting complex new subunits and regulators. Anna Rev Biochem, 1999, 68, 583-609. 

Reimann, j. D., et al., Emil is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cdl, 2001, 105(5), 645-55. 

Zachaeiae, W. et al. Mass spec-trometric analysis of the anaphase-promoting complex from yeast identification of a subunit related... 

Yu, H. et al. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science 1998, 279, 1219-22. 

A common feature of the solubihty curves, as outlined in Fig. 16, is the exponential increase with the pressure due to the increasing density of CO2. From the solubility measurements [125], it can be concluded that the modification of phosphines by fluorous substituents is not necessarily required to reach sufficient solubilities of the corresponding metal complexes in SCCO2. In particular, alkyl substitution on phosphorus promotes complex solubility. Additional aryl groups, e.g., in lb and 4b, cause a reduced solubility of the corresponding complexes. Moreover, trans-Co2(CO)6 (PC6H5)3 2 (7b) is completely insoluble in SCCO2. 

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