Group 7 metal-promoted oxidations epoxidation by salen manganese complexes

Group 7 metal-promoted oxidations epoxidation by salen manganese complexes 

Preparation of (1S,2/7)-1,2-epoxy-1,2,3,4 tetrahycb onaphthaiene (Structure 16). Asymmetric epoxidation using NaOCl catalysed by Jacobsen s chiral manganese salen complex (Structure 17), 

Caution Employ the standard precautions outlined in the introduction to this chapter for this reaction. 

Clean all glassware sequentially in soap solution, water, and acetone. Allow the acetone to evaporate and then dry the glassware in an electric oven (105 0 for at least 1 h. 

Place 13 mL of sodium hypochlorite solution (NaOCI, ca. 0.8 M) in a 50 mL Erlenmeyer flask. Buffer this by adding 5 mL of sodium phosphate (Na2HP04) solution (0.05 M) and adjust the pH of the solution to about 11 using a few drops of 1 M NaOH. Cool the solution in an ice-water bath. 

---