Proguanil hydrochloride

Materials Required Proguanil hydrochloride 0.6 g ammoniacal cupric chloride solution (dissolve 22.5 g of copper (II) chloride in 200 ml of DW and mix with 100 ml of 13.5 M ammonia) NO. 4 sintered-glass crucible mixture of dilute solution of ammonia and DW (1 5). 

Theory Gravimetric analysis of proguanil hydrochloride involves the precipitation of the proguanil-cupric complex that results on the addition of ammoniacal cupric chloride solution to a solution of proguanil hydrochloride. The reaction can be expressed by the following equation ... 

Looareesuwan S et al. Malarone (atovaquone and proguanil hydrochloride) A review of its clinical development for treatment of malaria. Am J Trop Med Hyg 1999 60 533-541. 

Although the British Pharmacopeia (BP) directs that proguanil hydrochloride should be protected from light, studies suggest that it is a very stable compound with only small amounts of its major decomposition product (4-chloroaniline) formed during thermal and photochemical stress.188... 

Colour Test. To 10 ml of a saturated solution of proguanil hydrochloride add 1 drop of 10% copper sulphate solution and... 

Infra-red Spectrum. Principal peaks at wavenumbers 1534,1635, 1492, 1575, 1600, 1170 (proguanil hydrochloride, KBr disk). 

Dihydralazine Sulphate Oxyphenisatin Acetate Proguanil Hydrochloride Ethacridine Lactate... 

Malarone (atovaquone and proguanil hydrochloride) 4 tablets once daily for 3 days. 

Anabwani G, Canfield CJ, Hutchinson DB. Combination atovaquone and proguanil hydrochloride vs. halofantrine for treatment of acute Plasmodium falciparum malaria in children. Pediatr Infect Dis J 1999 18(5) 456-61. 

A few members of this class of compounds are described below, viz., Proguanil hydrochloride Cycloguanil embonate Chlorproguanil Bromoguanil. 

A. Proguanil Hydrochloride BAN, Proguanil INN, Chlorguanide Hydrochloride USAN,... 

Condensation of/>-chlorophenyl guanidine with iso-propyl eyanamide gives the proguanil base which on treatment with one mole of hydroehloric acid yields proguanil hydrochloride. 

Paludrine (proguanil hydrochloride) the wonder drug for malaria gets metabolizsed to its active form cycloguanil in vivo. 

Malarone (Atovaquone/Proguanil hydrochloride). GlaxoSmithKline UK. UK Summaiy of product characteristics, June 2007. 

Prilocaine hydrochloride Primaquine phosphate Procainamide hydrochloride Procaine hydrochloride Procyclidine hydrochloride Progesterone Proguanil hydrochloride Promazine hydrochloride Promethazine hydrochloride Propantheline bromide Prothionamide Prothipendyl hydrochloride Protriptyline hydrochloride Proxyphylline... 

Skin Bullous erythema multiforme occurred in a patient who took atovaquone and proguanil hydrochloride (Malarone ) [12 ]. 

The assay of proguanil hydrochloride depends on the precipitation of a copper complex of the base and the official method is as follows ... 

For assay of the tablets, shake a quantity of the powdered tablets equivalent to 1 g of proguanil hydrochloride with 100 ml of water continuously for one hour, filter and determine by the method given above using 50 ml of the filtrate. 

Mefloquine hydrochloride tablets 250 mg. Primaquine phosphate tablets 7.5 or 15 mg. Proguanil hydrochloride tablets 100 mg. 

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