Prilocaine hydrochloride

Chemical Name N-(2-methylphenyl)-2-(propylamino)-propanamide hydrochloride Common Name Propitocaine hydrochloride 

Trade Name Manufacturer Country Year Introduced 

One mol of a-bromopropio-ortho-toluidide is mixed with a solution of 3 mols of n-propyl-amine in 500 ml of water-free benzene and the reaction mixture is heated in an autoclave to 80°C for 8 hours. After cooling the reaction mixture is treated as described above. The base is obtained as a colorless oil. BP 159 162°C/0.1 mm. Yield 55%. The base is then converted to the hydrochloride by reaction with HCI. 

---

Prilocaine hydrochloride [1786-81-8] is also similar in profile to Hdocaine, although prilocaine has significantly less vasodilator activity. Prilocaine is the least toxic of the amino amide local anesthetics. However, its tendency to cause methemoglobinemia, especially in newborns, has eliminated its use in obstetric surgery. 

Fig. 9.2. Flowchart of prilocaine hydrochloride solid state forms and melt with transformation temperatures under ambient pressure conditions (left) and semi-schematic energy/temperature diagram of the polymorphs (right). Key H, enthalpy G, Gibbs free energy AHf, heat of fusion Liq, liquid phase (melt). Reproduced from [36]...

Liquid dosage forms often can be directly asayed or simply diluted with water or mobile phase prior to testing. Benzethonium chloride tincture, prilocaine hydrochloride [3, pp. 173 and 1287], and numerous biological products such as OncoScint CR/OV (a monoclonal antibody DTPA conjugate) are examples. 

Infra-red Spectrum. Principal peaks at wavenumbers 1695,1543, 766, 754, 1299, 1258 (prilocaine hydrochloride, KBrdisk). 

Dose. Maximum dose of prilocaine hydrochloride, 400 mg, or 600 mg in solutions with adrenaline. 

Preservation of samples, 114,116 Presinol, 764 Prestim, 375, 1026 Presun 4, 847 Presun 8, 340 Prethcamide, 495 Priadel, 708 Priamide, 690 Prilocaine, 920 Prilocaine hydrochloride, 920 Primachin, 921 Primaclone, 922 Primalan, 735 Primal(s), 334 Primaquine, 921 Primaquine phosphate, 921 Primidone, 25, 922 therapeutic drug monitoring, 109 Primogyn C, 596 Primogyn Depot, 831 Primolut N, 823 Primolut Nor, 823 Primoteston-Depot, 1003 Primperan, 776... 

Examples Lignocaine Hydrochloride Prilocaine Hydrochloride Mepivacaine Hydrochloride Bupivacaine Hydrochloride Pyrrocaine Hydrochloride Diperodon. 

It is a local anaesthetic of the amide type which is employed for surface, infiltration and nerve block anaesthesia. Its duration of action is in between the shorter-acting lidocaine and longer-acting mepivacaine. It possesses less vaso-dilator activity than lidocaine and hence may be used without adrenaline. Therefore, solutions of prilocaine hydrochloride are specifically beneficial for such patients who cannot tolerate vasopressor agents patients having cardiovascular disorders, diabetes, hypertension and thyrotoxicosis. 

Prilocaine hydrochloride Primaquine phosphate Procainamide hydrochloride Procaine hydrochloride Procyclidine hydrochloride Progesterone Proguanil hydrochloride Promazine hydrochloride Promethazine hydrochloride Propantheline bromide Prothionamide Prothipendyl hydrochloride Protriptyline hydrochloride Proxyphylline... 

A 2.5-month-old boy developed cyanosis on his lips and entire body 15 minutes after circumcision, during which prilocaine hydrochloride 30 mg had been injected subcutaneously [71 ]. The cyanosis resolved after a single intravenous dose of ascorbic acid (vitamin C) 300mg/kg methylthioninium chloride was not available. 

Lidocaine showed slow diffusion in all ME systems suggesting association with the lipophilic phase. Prilocaine hydrochloride also showed slow diffusion behavior and the authors explained this by association of the drug with the surfactant... 

Prilocaine hydrochloride is freely soluble in water and alcohol and slightly soluble in chloroform. 

---