Production prioritizing

Many molecular properties can be calculated and used for product prioritization and selection (R05, structure-Alert, more ADME T estimations, project specific activity model, etc) ... 

Another key pillar is the Integrated Product Policy (IPP). IPP aims to reduce the environmental impact of products. Relevant initiatives include pilot projects, the creation of an EU Platform on life cycle assessment (EGA), and product prioritization. 

The so-called Q7 tools and techniques, Cause and Effect Diagrams, Pareto Analysis, etc. (Bicheno, 1994 Dale and McQuater, 1998 Straker, 1995), are applicable to any stage of the product development process. Indeed they support the working of some of the techniques mentioned, for example using a Pareto chart for prioritizing the potential risks in terms of the RPN index for a design as determined in FMEA (see Appendix III). 

Subcontractor development should not be limited to the assessment for compliance to ISO/TS 16949 as indicated in Note 1. The standard contains the minimum requirements and, with the requirement for continuous improvement, it may be necessary to work with some of your subcontractors in order to develop their capability to improve process capability and delivery schedules or reduce avoidable costs. You can t develop all your subcontractors and hence Note 2 of the standard indicates that you should prioritize subcontractors for development based upon performance and importance of product or service supplied. 

The relevance of the information to the process worker is another factor in design. This principle is often violated with the introduction of new VDU-based computer systems where information needed to assist computer scientists or production managers is mixed with information relevant for the safe operation of the plant. Clearly, some kind of structuring and prioritization will be necessary for the different users of the system. 

Confirm Measurement System > Baseline In-Process Product Parameters (Control, Capability) > Identify/Prioritize Process Steps > Identify Critical Process Parameters... 

Deciding which risk-reduction method to use maybe difficult. In many instances, appropriate decisions can be made without resorting to quantitative techniques. However, in some cases, particularly when the options are costly, quantitative risk analysis (QRA) and risk-based decision-making approaches may be an effective basis for measuring the improvement in safety arising from the proposed options. These approaches can also be used in prioritizing safety improvements and balancing cost and production issues. 

On the other hand, there is a need for reducing energy consumption while producing hydrogen through electrolysis in order to reduce the cost of hydrogen production when obtained from water in order to prioritize its production independently from hydrocarbons. 

The situation is not different in the pharmaceutical world, where marketing strategies are developed on the basis of expectations of their effects on drug sales, market penetration, perceived quality, etc. Such strategies are often the product of implicit mental models, and are effective when they have their desired impact. But mental models are difficult to communicate, impossible to analyze or quantify, and hard to prioritize. As such, they often result in suboptimal decisions when it comes to strategy development and brand planning. 

The ACS GCI Pharmaceutical Roundtable recently set out to prioritize the areas of chemical synthesis where unproved methodology would realize the greatest beneficial impact on pharmaceutical production. This resulted in the publication of a wish list of currently utilized transformations that require better reagents and aspirational transformations that would provide shorter routes were they available (Table 1.3). ... 

Ertl P, Roggo S, Schuffenhauer A. (2008) Natural product-likeness score and its application for prioritization of compound hbraries. J Chem Inf Model 48 68-74. 

In the EU, 141 of existing high production volume chemical substances have been prioritized for an in-depth risk assessment, see Section 2.4.1.4 for details. 

An ever-expanding list of occupational and environmental laws and regulations affect schools and colleges. The corresponding responsibilities require school administrators and staff to not only be aware of the various hazardous chemical regulations, but also to expend substantial time and dollars to assure that liabilities are minimized. Compliance with many of these regulations can be simplified, or at least, effectively focused and prioritized, if hazardous chemical and product information is readily available (Forum for Scientific Excellence, 1990). 

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