Probenecid Cimetidine

Randinitis EJ, Koup JR, Bron NJ, Hounslow NJ, Rausch G, Abel R, Vassos AB, Sedman AJ. Drug interaction studies with clinafloxacin and probenecid, cimetidine, phenytoin and warfarin. Drugs (1999) 58 (Suppl 2), 254-5. 

Drugs that affect NSAIDs include the following Bisphosphonates, cholestyramine, cimetidine, colestipol, cyclosporine, diflunisal, DMSO, fluconazole, ketoconazole, phenobarbital, phenylbutazone, probenecid, rifampin, ritonavir, salicylates, sucralfate. 

Drugs that may affect benzodiazepines include alcohol, antacids, barbiturates, cimetidine, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, oral contraceptives, narcotics, probenecid, propoxyphene, propranolol, ranitidine, rifampin, scopolamine, theophylline, and valproic acid. 

Drugs that may affect benzodiazepines include alcohol/CNS depressants, cimetidine, oral contraceptives, disulfiram, isoniazid, probenecid, rifampin, smoking, theophyllines, and macrolides. 

Drugs that may affect valacyclovir include cimetidine/probenecid. 

Drugs that may interact with zalcitabine include antacids, chloramphenicol, cisplatin, dapsone, didanosine, disulfiram, ethionamide, glutethimide, gold, hydralazine, iodoquinol, isoniazid, metronidazole, nitrofurantoin, phenytoin, ribavirin, vincristine, cimetidine, metoclopramide, amphotericin, aminoglycosides, foscarnet, antiretroviral nucleoside analogs, pentamidine, and probenecid. 

Famciclovir (Famvir) [Antiviral/Synthetic Nucleoside] Uses Acute h pes zoster (shingles) genital h pes Action X Viral DNA synth Dose Zoster 500 mg PO q8h x7 d Simplex 125-250 mg PO bid X w/ renal impair Caution [B, -] Contra Component sensitivity Disp Tabs SE Fatigue, dizziness, HA, pruritus, N/D Interactions t Effects cimetidine, probenecid, theophylline t effects OF digoxin EMS None OD Sxs unknown, but may cause hallucinations, Szs and reduced kidney Fxn... 

Un, acute exacerbation of chronic bronchitis prophylaxis in transurethral procedures Action Quinolone antibiotic -1- DNA gyrase. Dose 400 mg/d PO X w/ renal insuff, avoid antacids Caution [C, —] Interactions w/ cation-containing products Contra Quinolone all gy, children <18 y,T QT interval, X Disp Tabs SE NA/ /D, abd pain, photosens, Szs, HA, dizziness, tendon rupture, periph al neuropathy, pseudomembranous cohtis, anaphylaxis Interactions t Effects W/ cimetidine, probenecid T effects OF cyclosporine, warfarin, caffeine X effects W/ antacids EMS Monitor ECG for TqT int val, esp in pts taking class lA/III antiarrhythmics monitor ECG and BP for signs of h5 povolemia and electrol5rte disturbances (hypokalemia) d/t D T risk of photosensitivity Rxns OD May cause NA /D, confusion and Szs symptomatic and supportive... 

Concurrent use of nephrotoxic agents may enhance the potential for nephrotoxicity. Probenecid and cimetidine decrease acyclovir clearance and increase exposure. Somnolence and lethargy may occur in patients receiving zidovudine and acyclovir. 

Potential drug interactions include an increased AUC of zalcitabine when administered in combination with probenecid or cimetidine and decreased bioavailability when zalcitabine is coadministered with antacids or metoclopramide. Lamivudine inhibits the phosphorylation of zalcitabine in vitro, potentially interfering with its efficacy. 

OCT2 to the tubular secretion of cimetidine and famotidine. Furthermore, a great interspecies difference was found in the effect of probenecid, which had no effect on the tubular secretion of famotidine and cimetidine in rats (Fig. 8) (348). Two factors have been proposed for this interspecies difference (1) expression of Octl only in rodent kidney and (2) greater transport activity of famotidine by OAT3 than by Oat3 (120). In monkey, as in the case in human, probenecid had significant effect on the renal elimination of famotidine, but not for cimetidine (152). 

De Bony F, Tod M, Bidault R, et al. Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir. Antimicrob Agents Che-mother 2002 46 458 163. 

Yasui-Furukori N, Uno T, Sugawara K, et al. Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics. Clin Pharmacol Ther 2005 77 17-23. 

Gisclon LG, Boyd RA, Williams RL, et al. The effect of probenecid on the renal elimination of cimetidine. Clin Pharmacol Ther 1989 45 444-452. 

Boom SP, Meyer I, Wouterse AC, et al. A physiologically based kidney model for the renal clearance of ranitidine and the interaction with cimetidine and probenecid in the dog. Biopharm Drug Dispos 1998 19 199-208. 

Cephalosporins Cimetidine Furosemide NSAIDs Probenecid Ranitidine Tetracycline Various anticancer ... 

The nephrotoxicity of dsplatin is reduced in humans [132], mice [133] and dogs [134] by co-admin-istration of probenecid, suggesting that cisplatin is transported by the PAH transport system. It has been proposed that platinum, hke other nephrotoxic metal ions such as mercury and potassium dichromate, are taken up by tubular cells as sulphydryl conjugate through a probenecid-sensitive pathway [133]. However, cisplatin might also be transported by the organic cation transport system, since quinidine, cimetidine and ranitidine inhibited its net secretion flux in the dog kidney [134]. 

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