Furosemide Cimetidine

Drugs that may affect metformin include alcohol, cationic drugs, cimetidine, furosemide, iodinated contrast material, and nifedipine. 

Cephalosporins Cimetidine Furosemide NSAIDs Probenecid Ranitidine Tetracycline Various anticancer ... 

There is a risk of acute renal failure when iodi-nated contrast material that is used for radiological studies is administered with metformin. Metformin therapy is stopped for 48 hours before and after radiological studies using iodinated material. Alcohol, amiloride, digoxin, morphine, procainamide, quini-dine, quinine ranitidine, triamterene, trimethoprim, vancomycin, cimetidine, and furosemide all increase the risk of hypoglycemia. There is an increased risk of lactic acidosis when metformin is administered with the glucocorticoids. 

Drugs that can precipitate lactic acidosis in patients taking metformin include ACE inhibitors, thiazide diuretics, NSAIDs, and drugs such as furosemide, nifedipine, cimetidine, amiloride, triamterene, trimethoprim, and digoxin, which are all secreted in the renal tubules, compete with metformin, and can contribute to increased plasma metformin concentrations (76). 

Figure 6.17 The classification of 42 drugs in the (solubility-dose ratio, apparent permeability) plane of the QBCS. The intersection of the dashed lines drawn at the cutoff points form the region of the borderline drugs. Key 1 acetyl salicylic acid 2 atenolol 3 caffeine 4 carbamazepine 5 chlorpheniramine 6 chlorothiazide 7 cimetidine 8 clonidine 9 corticosterone 10 desipramine 11 dexamethasone 12 diazepam 13 digoxin 14 diltiazem 15 disopyramide 16 furosemide 17 gancidovir 18 glycine 19 grizeofulvin 20 hydrochlorothiazide 21 hydrocortisone 22 ibuprofen 23 indomethacine 24 ketoprofen 25 mannitol 26 metoprolol 27 naproxen 28 panadiplon 29 phenytoin 30 piroxicam 31 propanolol 32 quinidine 33 ranitidine 34 salicylic acid 35 saquinavir 36 scopolamine 37 sulfasalazine 38 sulpiride 39 testosterone 40 theophylline 41 verapamil HC1 42 zidovudine.

Rogers HJ, Morrison P, House FR, Bradbrook ID. Effect of cimetidine on the absorption and efficacy of orally administered furosemide. Int J Chn Pharmacol Ther Toxicol 1982 20(1) 8-11. 

Recommendations have been presented for correction of theophylline doses dnring concomitant medication with some of the above dmgs (SEDA-8, 130) (45). Concomitant therapy with aUopnrinol, cimetidine, erythromycin, furosemide, isoprenahne, or propranolol requires a reduction in dose of abont 20-30% for oleandomycin the reduction shonld be abont 50%. 

NSAiDs, giafenin, ASA, fenoprofen, naproxen, phenyibutazone, piroxacam, tolemetin, zomepirac, contrast media, suifonamides, thiazides, phenytoin, furosemide, aiiopurinoi, cimetidine, omeprazole, phenindione. ... 

Allergic interstitial nephritis Penicillins, rifampin, sulfonamides, thiazides, cimetidine.phenytoin, allopurinol, furosemide, NSAIDS, ciprofloxacin, pantoprazole, omeprazole, atazanavir, bevacizumab Rash, fever, eosinophilia, eosinophiluria, pyuria... 

Drugs that are commonly associated with vasculitis are ACE inhibitors, amiodarone, ampicillin, cimetidine, coumadin, furosemide, hydantoins, hydralazine, NSAIDs, pyrazolons, quinidine, sulfonamides, thiazides, and thiouracils. 

Propylene glycol X 1.5 X Furosemide, atenolol, mannitol, ranitidine, acyclovir, cimetidine, hydrocloro thiazide Rege et ah, 2001... 

Transporter absorptive effects predominant Examples. Acyclovir, Amiloride -, Amoxicillin Atenolol Atropine, Bidisomide Bisphosphonates Captoprit, Cefazolin Cetirizine Cimetidine Ciprofloxacin, Cloxacillin Dicloxacillin Erythromycin - -, Famotidine Fexofenadine Folinic acid Furosemide, Ganciclovir Hydrochlorothiazide, Lisinopril Metformin Methotrexate, Nadolol Penicillins Pravastatin Ranitidine Tetracycline Trimethoprim Valsartan Zalcitabine... 

Noninterfering acetaminophen, caffeine, cimetidine sulfoxide, diazepam, digoxin, flura-zepam, furosemide, methyldopa, minoxidil, propranolol, quinidine, sulfinpyrazone Interiering procainamide, tolazamide... 

Noninterfering acetaminophen, amiloride, aspirin, atenolol, chlorothiazide, cimetidine, cyclopenthiazide, diazepam, furosemide, indapamide, labetalol, lorazepam, metoprolol, phenytoin, propranolol, ranitidine, salicylic acid, theophylline... 

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