Sensitization pathways

Hirst How long does it take to activate a sensitization pathway ... 

Yi, A.K., Klinman, D.M., Martin, T.L., Matson, S. and Krieg, A.M. (1996c) Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J. Immunol., 157, 5394-5402. 

Dynamic spectral sensitization (16). Based upon the kinetic scheme given above (Scheme 1), the dynamic sensitization pathway leading to the desired product, e.g. by electron transfer, ray be written as shown in Equation 2. 

The interaction of delta opioid receptor selective ligands with its respective receptor has been reported to hyperpolarize neurons. Hyperpolarization of neurons in the delta opioid sensitive pathway may play a major... 

Rodriguez, F.A., Escobales, N., and Maldonado, C. 1994. Brevetoxin-3 (Pbtx-3) inhibits oxygen consumption and increases Na+ content in mouse-liver slices through atetrodotoxin-sensitive pathway. Toxicon 32,1385—1395. 

Platelets have at least two G protein-mediated pathways that link receptors to PLC-P (Figure 2). Thrombin and platelet activating fector (PAF) receptors activate high affinity GTPase and PLC-P via pertussis toxin-sensitive and toxin-insensitive G proteins (139,146). hr contrast, activation of PLC-P via TP receptors is pertussis toxin-insensitive (139). The pertussis toxin-sensitive pathway is mediated by G,. Since Go, has not been demonstrated to reconstitute PLC-P stimulation in vitro (147), it is likely that activation of PLC-P via G, is mediated by GPy rather than Go. The toxin-sensitive pathway is mediated via a Gq femily G protein now known to be Go (140,148,149). 

In vitro and animal studies clearly point to a central role of several distinct but interconnected redox-sensitive pathways in the pathogenesis of inflammation [47]. It has been hypothesized that oxidative stress occurs as a result of the depletion of the cellular content of reduced glutathione. A sublethal oxidative stress can activate redox-sensitive kinase cascades and transcription factors, NF-kB and AP-1, with resulting increases in the expression of factors associated with an inflammatory response and cellular proliferation. Evidence has been collected suggesting that oxidative stress and the ensuing modification of the cellular redox status may be associated with the induction of cell death either via stimulation of apoptosis and/or necrosis. It is well known that cell death is a common feature of the inflammatory process [48]. 

Carr DJ, DeCosta BR, Jacobson AE, Rice KC, Blalock JE (1990) Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathway. J Neuroimmunol 28 53-61. 

The nephrotoxicity of dsplatin is reduced in humans [132], mice [133] and dogs [134] by co-admin-istration of probenecid, suggesting that cisplatin is transported by the PAH transport system. It has been proposed that platinum, hke other nephrotoxic metal ions such as mercury and potassium dichromate, are taken up by tubular cells as sulphydryl conjugate through a probenecid-sensitive pathway [133]. However, cisplatin might also be transported by the organic cation transport system, since quinidine, cimetidine and ranitidine inhibited its net secretion flux in the dog kidney [134]. 

Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, et al. 2000. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130 2413-2419. (The first report of the mechanism underlying the stimulation of protein synthesis by leucine in the whole animal)... 

Oda, T., Iwaoka, J., Komatsu, N. and Muramatsu, T. (1999) Involvement of /V-acetylcysteine-sensitive pathways in ricin-induced apoptotic cell death in U937 cells. Biosci Biotechnol Biochem, 63, 341-348. 

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