PRIORITISATION METHOD

Incorporating Social Dimensions into a Prioritisation Method... 

The proposed systems framework s prioritisation method can help decide on measures and monitoring activities that target the control of the probability or the extent of further regulatory action being necessary, for example ... 

EU risk assessment and the application of the systems framework decision-making matrix both indicate otherwise. The prioritisation method could also isolate several substances that should be given particularly low priorities at the EU level (e.g., BA, butadiene, TCE) which demonstrates some of the inefficiencies of the current regulatory system that could continue under REACH. 

Risk-Benefit Target-setting schemes for countries to establish levels of safety in national territories that go beyond minimum EU standards Member State permitting option for controlling occupational exposures Prioritisation method for regulatory decision-making... 

The current situation with regard to risk assessment in the use of a wide range of different types of flame retardant is reviewed with respect to EEC council regulation No.793/93. The countries responsible for risk assessment on particular materials are listed and tonnages of materials used are noted. Three methods of prioritisation are used based on quantity used, environmental hazard potential and environmental risk ranking. 6 refs. 

The need to develop a method of prioritisation under REACH is highlighted by the fact that approximately 3,700 substances are anticipated to be registered under REACH within the first 3.5 years of implementation (Section 2.5.1). In the history of chemical regulation, such a large number of risk assessments have never been generated over such a short time period. Several substances will be... 

The REACH legislation stipulates prioritisation for evaluation and authorisation based only on hazardous properties, production and use volumes, and whether a chemical has a wide dispersive use . Nevertheless, it is possible that the REACH TGDs could incorporate methods for prioritisation for evaluation, restriction or authorisation based on the Dutch SOMS or the method proposed in the UK RCEP s report Chemicals in Products (refer to Section 5.2). The SOMS method for prioritisation according to hazard and... 

The method of qualitative rankings developed in this thesis is rather similar to the system for prioritisation developed by [12]. Klinke and Renn propose that regulatory action should be prioritised according to the following six questions ... 

The method for prioritisation has been devised for EU decisionmaking in terms of executing decisions, a wide number of actors can often be expected to be involved. Regulatory action covers a broad... 

MELD and PELD are scoring systems often used as a method of prioritising patients awaiting liver transplantation. Patients with a higher score are deemed to require a transplant more urgently than those with a lower score. The MELD system is for patients 12 years and older and... 

Bohm, H. f. Prediction of Binding Constants of Protein Ligands A Fast Method for the Prioritisation of Hits Obtained from De-novo Design or 3D Database Search Programs,/. Comput.-Aided Mol. Des. 1998, 32, 309-323. 

One of the key tools in evaluating virtual screening performance is some measure of enrichment, whether by ROC curves, enrichment factor and so on. What one wants to know is whether a screening method identifies the actives early in the overall prioritised list of compounds. Truchon and Bayley" have performed a theoretical analysis to show that ROC curves may not be ideal for this purpose, despite their widespread use (and advocacy). A method can get a good ROC score, yet still fail to identify any actives in the top 20%. They propose a new metric based on an enhanced form of the ROC curve called BEDROC, which, via a parameter... 

Assessment and judgement of the 15 more unusual radionuclides, associated waste streams and related uncertainties was used to prioritise the benefit of development of new chemical/radiochemical analysis methods as compared to further theoretical calculations. 

The need for reasoning in Meteor is self-evident. In an unconstrained analysis, an unmanageable number of metabolic pathways would be generated and this is not always useful or desirable. Rather than allowing this to happen, reasoning affords a method by which biotransformations can be prioritised and the more likely results, rather than all possible outcomes, displayed. However, users of the program may set the processing constraints such that a query can... 

One may choose to prioritise areas which are likely to be associated with the greatest clinical risk or, if necessary, those for which most information is currently available. In this way, the hazard register gradually emerges from a number of assessment workshops in a logical and methodical manner in association with the relevant experts. 

In previous chapters the focus has been on risk identification and the systematic methods used to characterise hazards. Our next task is to exanune the practicalities of evaluating risk - studying the properties of hazards and their causes to establish the degree of risk and therefore its acceptability. Doing so allows us to prioritise those hazards which require further risk nutigation. 

This leads us to the notion of detectability - the extent to which we are able to identify deviation from the system s requirements or normal operation. Such is the importance of detectability that in some systematic methods of hazard identification such as FMECA detectability is included in the calculation of risk itself (see Sect. 13.6.1). In this way the lack of detectability is given an equal weight to likelihood and severity in deriving the Risk Priority Number, the main driver for prioritising corrective actions. 

A final, yet fundamental point to be made with regard to safety management systems is that their all-encompassing nature often means that safety can easily become cluttered with inspections, rules, objectives and methods for measurement. Yet when we look beyond their titles, within the Health and Safety Executive s safety management guidance, swift prioritisation is made of the ideas of hazard, harm and risk something that often forms only a part of safety management systems. 

Bohm. H.J. Prediction of binding constants of protein ligands A fast method for the prioritisation of hits obtained from de-novo design or 3D-database search programs. J. Comput. Aided Mol. Des. 1998. 12. 309- 323. 

Systematic use of data mining tools in a large spontaneous ADR database will identify large numbers of statistical signals. Evaluating all of them in detail would have major resource implications but many will turn out not to be real or to require no action. Possible signals have often been evaluated or dismissed on the basis of subjective judgements but two methods of prioritisation have been proposed ... 

This paper suggests a method for semi-quantitative cost-effectiveness analysis to categorise safety measures for road tunnels. The method provides a practical approach to systemise and prioritise between a large number of alternative safety measures. As a basis for categorization of alternative safety measures, attention is given to expected cost and expected risk reducing effect as in a traditional cost-effectiveness analysis, as well as imcertainties. 

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